Agreement between predicted risk and prevalence of Down syndrome in second-trimester triple-marker screening in Japan

被引：0

作者：

Onda, T

Tanaka, T

Takeda, O

Kitagawa, M

Kuwabara, Y

Yamamoto, H

Iinuma, K

Shimomura, K

机构：

[1] Jikei Univ, Sch Med, Dept Obstet & Gynaecol, Tokyo 105, Japan

[2] Fuji City Hosp, Fuji, Shizuoka, Japan

[3] Natl Ohkura Hosp, Tokyo, Japan

[4] Juntendo Univ, Sch Med, Tokyo 113, Japan

[5] Sapporo Med Univ, Sch Med, Sapporo, Hokkaido, Japan

[6] IG Clin, Tokyo, Japan

[7] Genzyme Japan KK, Tokyo, Japan

来源：

PRENATAL DIAGNOSIS | 1998年 / 18卷 / 09期

关键词：

triple-marker screening test; Down syndrome; prediction; accuracy; follow-up study;

D O I：

10.1002/(SICI)1097-0223(199809)18:9<956::AID-PD370>3.0.CO;2-R

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Based on 9350 pregnant Japanese women who were screened by serum triple-marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r=0.98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow-up study, implemented in our prospective intervention programme. (C) 1998 John Wiley & Sons, Ltd.

引用

页码：956 / 958

页数：3

共 36 条

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