Relationship Between White Matter Abnormalities and Neuropsychological Measures in Children With ADHD

被引:10
作者
Saenz, Ariadna Albalara [1 ]
Villemonteix, Thomas [1 ,2 ]
Slama, Hichem [1 ]
Baijot, Simon [1 ,3 ]
Mary, Alison [1 ]
Baleriaux, Danielle [4 ]
Metens, Thierrr [4 ]
Kavec, Martin [4 ]
Peigneux, Philippe [1 ]
Massat, Isabelle [1 ,5 ]
机构
[1] Univ Libre Bruxelles, Brussels, Belgium
[2] Paris 8 Vincennes St Denis Univ, St Denis, France
[3] Queen Fabiola Childrens Univ Hosp, Brussels, Belgium
[4] Erasme Univ Hosp, Brussels, Belgium
[5] FNRS Natl Fund Sci Res, Brussels, Belgium
关键词
ADHD; inhibition; working memory; DTI; TBSS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SUPERIOR LONGITUDINAL FASCICULUS; WORKING-MEMORY; RESPONSE-INHIBITION; SUSTAINED ATTENTION; SPATIAL STATISTICS; DIFFUSION; MICROSTRUCTURE; HYPERACTIVITY; METAANALYSIS;
D O I
10.1177/1087054718787878
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Objective: Using Diffusion Tensor Imaging (DTI), to investigate microstructural white matter differences between ADHD and typically developing children (TDC), and their association with inhibition and working memory performance usually impaired in ADHD. Method: Fractional anisotropy (FA) and mean diffusivity (MD) were estimated in 36 noncomorbid children with a Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV-TR) diagnosis of combined type ADHD and 20 TDC. Correlations between FA/MD and Stop Signal Task and N-Back performance parameters were computed. Results: Working memory performance was significantly associated with MD in the superior longitudinal fasciculus (SLF) and the cingulum in the ADHD group. No between-group differences in FA/MD reached significance, after controlling for between-group head motion differences. Conclusion: The association between white matter integrity in the cingulum and the SLF and working memory performance confirms previous studies. Our results also show that when critical conditions are controlled (age, comorbidity, head motion), no ADHD-related structural abnormality (FA/MD) are observed, in line with prior suggestions.
引用
收藏
页码:1020 / 1031
页数:12
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