Structural and functional changes in the heart of adult patients with osteogenesis imperfecta: Case-control study

被引：6

作者：

Hernandez Jimenez, Veronica ^{[1
]}

Saavedra Falero, Jesus ^{[2
]}

Alberca Vela, Maria Teresa ^{[2
]}

Mata Caballero, Rebeca ^{[2
]}

Rosado Sierra, Jose Antonio ^{[3
]}

Pavon de Paz, Isabel ^{[3
]}

机构：

[1] Hosp Univ Rey Juan Carlos, Serv Cardiol, Madrid, Spain

[2] Hosp Univ Getafe, Serv Cardiol, Madrid, Spain

[3] Hosp Univ Getafe, Serv Endocrinol & Nutr, Madrid, Spain

来源：

MEDICINA CLINICA | 2018年 / 151卷 / 10期

关键词：

Osteogenesis imperfecta; Collagen; Echocardiography; Valvulopathy; Aortic root; DISEASE; INVOLVEMENT;

D O I：

10.1016/j.medcli.2018.02.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction and objectives: Osteogenesis imperfecta (OI) is a connective tissue disease characterised by an anomalous synthesis of type i collagen. Little is known about the cardiovascular affectation suffered by these patients. The most frequently described are valvular dysfunction and dilatation of the aorta. We wanted to analyse the structural and functional changes of the heart in adult patients with OI. Methods: We prospectively studied 82 patients with OI and compared them with 60 healthy subjects matched for age and sex. All of them underwent an echocardiographic study. Results: We found no differences in the incidence of valvulopathies compared to the control group. Our patients had a larger left atrium and larger left ventricle (LV) diameters adjusted for body surface area. Aortic root was significantly higher. LV ejection fraction in patients with OI was lower and they had higher pulmonary artery systolic pressure. Conclusions: Patients with 01 suffer structural and functional changes in the heart. A follow-up is recommended to observe the evolution of these changes. (C) 2018 Elsevier Espana, S.L.U. All rights reserved.

引用

页码：397 / 399

页数：3

共 10 条

[1] Heart disease in patients with osteogenesis imperfecta - A systematic review [J].

Ashournia, Hamoun ;

Johansen, Frank Ted ;

Folkestad, Lars ;

Diederichsen, Axel C. P. ;

Brixen, Kim .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 196 :149-157

[2] Cardiac abnormalities in osteogenesis imperfecta. Case-control echocardiographic study [J].

Bonilla Jimenez, Vanesa ;

Saavedra Falero, Jesus ;

Alberca Vela, Maria Teresa ;

Diaz Guardiola, Patricia ;

Iglesias Bolano, Paloma ;

Pavon, Isabel .

MEDICINA CLINICA, 2010, 135 (15) :681-684

[3] Ehlers-Danios syndromes and Marfan syndrome [J].

Callewaert, Bert ;

Malfait, Fransiska ;

Loeys, Bart ;

De Paepe, Anne .

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2008, 22 (01) :165-189

[4]

Karamifar H, 2013, IRAN J PEDIATR, V23, P513

[5] Valvular and Aortic Diseases in Osteogenesis Imperfecta [J].

Lamanna, Arvin ;

Fayers, Trevor ;

Clarke, Sophie ;

Parsonage, William .

HEART LUNG AND CIRCULATION, 2013, 22 (10) :801-810

[6] Impairment of diastolic function in adult patients affected by osteogenesis imperfecta clinically asymptomatic for cardiac disease: Casuality or causality? [J].

Migliaccio, Silvia ;

Barbaro, Giuseppe ;

Fornari, Rachele ;

Di Lorenzo, Gabriella ;

Celli, Mauro ;

Lubrano, Carla ;

Falcone, Stefania ;

Fabbrini, Elisa ;

Greco, Emanuela ;

Zambrano, Anna ;

Brama, Marina ;

Prossomariti, Giancarlo ;

Marzano, Sara ;

Marini, Mario ;

Conti, Francesco ;

D'Eufemia, Patrizia ;

Spera, Giovanni .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2009, 131 (02) :200-203

[7] Prevalence of Cardiovascular Disease and Cardiac Symptoms: Left and Right Ventricular Function in Adults With Osteogenesis Imperfecta [J].

Radunovic, Zoran ;

Steine, Kjetil .

CANADIAN JOURNAL OF CARDIOLOGY, 2015, 31 (11) :1386-1392

[8] Cardiovascular abnormalities in adults with osteogenesis imperfecta [J].

Radunovic, Zoran ;

Wekre, Lena L. ;

Diep, Lien M. ;

Steine, Kjetil .

AMERICAN HEART JOURNAL, 2011, 161 (03) :523-529

[9]

SILLENCE DO, 1978, LANCET, V1, P1041

[10] Myocardial Involvement in Patients With Osteogenesis Imperfecta [J].

Soma, Katsura ;

Abe, Hajime ;

Takeda, Norihiko ;

Shintani, Yukako ;

Takazawa, Yutaka ;

Kojima, Toshiya ;

Fujiu, Katsuhito ;

Semba, Hiroaki ;

Yamashita, Hiroshi ;

Hirata, Yasunobu ;

Fukayama, Masashi ;

Nagai, Ryozo .

INTERNATIONAL HEART JOURNAL, 2012, 53 (01) :75-77

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