MicroRNAs: the fine-tuners of Toll-like receptor signalling

被引：732

作者：

O'Neill, Luke A. ^{[1
]}

Sheedy, Frederick J. ^{[2
]}

McCoy, Claire E. ^{[3
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Dublin, Ireland

[2] NYU, Langone Med Ctr, New York, NY 10016 USA

[3] Monash Univ, Monash Inst Med Res, Clayton, Vic 3168, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 03期

基金：

爱尔兰科学基金会;

关键词：

DOMAIN-CONTAINING INOSITOL-5-PHOSPHATASE; ANTIVIRAL INNATE IMMUNITY; MESSENGER-RNA; BINDING-PROTEIN; INFLAMMATORY RESPONSE; TRANSCRIPTION FACTORS; DOWN-REGULATION; EXPRESSION; CELLS; TARGET;

D O I：

10.1038/nri2957

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation and to allow for tissue repair and the return to homeostasis after infection and tissue injury. MicroRNAs (miRNAs) have emerged as important controllers of TLR signalling. Several miRNAs are induced by TLR activation in innate immune cells and these and other miRNAs target the 3' untranslated regions of mRNAs encoding components of the TLR signalling system. miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases.

引用

页码：163 / 175

页数：13

共 135 条

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