Neutrophil chemiluminescence during phagocytosis is inhibited by abnormally elevated levels of acetoacetate: Implications for diabetic susceptibility to infections

被引：34

作者：

Saeed, FA ^{[1
]}

Castle, GE ^{[1
]}

机构：

[1] St Marys Coll, Dept Biol, Moraga, CA 94575 USA

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1998年 / 5卷 / 05期

关键词：

D O I：

10.1128/CDLI.5.5.740-743.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human neutrophils by a chemiluminescence assay exhibit diminished phagocytic activity in the presence of abnormally high levels of the serum metabolite acetoacetate. These findings, along with our previous evidence demonstrating myeloperoxidase inhibition by acetoacetate, implicate metabolic ketosis in the inhibition of neutrophil microbicidal activity and thus in increased susceptibility to infections.

引用

收藏

页码：740 / 743

页数：4

相关论文

共 13 条

[1] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[2]

HARRISON JE, 1976, J BIOL CHEM, V251, P1371

[3] ACETOACETATE IS AN ELECTRON-DONOR TO MYELOPEROXIDASE AND A PROMOTER OF MYELOPEROXIDASE-CATALYZED FATTY-ACID PEROXIDATION [J].

HARRISON, JE ;

SAEED, FA .

BIOCHEMICAL MEDICINE, 1981, 26 (03) :339-355

[4] RADICAL ACETOACETATE OXIDATION BY MYELOPEROXIDASE, LACTOPEROXIDASE, PROSTAGLANDIN SYNTHETASE, AND PROSTACYCLIN SYNTHETASE - IMPLICATIONS FOR ATHEROSCLEROSIS [J].

HARRISON, JE ;

SAEED, FA .

BIOCHEMICAL MEDICINE, 1983, 29 (02) :149-163

[5]

HARRISON JE, 1981, ACS ANN M ABSTR

[6] PHARMACOLOGICAL CONTROL OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE DEGRANULATION BY FENAMATES AND INHIBITORS OF RECEPTOR-MEDIATED CALCIUM-ENTRY AND PROTEIN-KINASE-C [J].

KANKAANRANTA, H ;

MOILANEN, E ;

LINDBERG, K ;

VAPAATALO, H .

BIOCHEMICAL PHARMACOLOGY, 1995, 50 (02) :197-203

[7]

KLEBANOFF SJ, 1978, NEUTROPHIL FUNCTIONA

[8] LEUKOCYTE MYELOPEROXIDASE DEFICIENCY AND DISSEMINATED CANDIDIASIS - ROLE OF MYELOPEROXIDASE IN RESISTANCE TO CANDIDA INFECTION [J].

LEHRER, RI ;

CLINE, MJ .

JOURNAL OF CLINICAL INVESTIGATION, 1969, 48 (08) :1478-+

[9] INTERACTION OF CANDIDA ALBICANS WITH HUMAN LEUKOCYTES AND SERUM [J].

LEHRER, RI ;

CLINE, MJ .

JOURNAL OF BACTERIOLOGY, 1969, 98 (03) :996-&

[10] REGULATION OF PHOSPHOLIPASE-D BY PROTEIN-KINASE-C IN HUMAN NEUTROPHILS - CONVENTIONAL ISOFORMS OF PROTEIN-KINASE-C PHOSPHORYLATE A PHOSPHOLIPASE D-RELATED COMPONENT IN THE PLASMA-MEMBRANE [J].

LOPEZ, I ;

BURNS, DJ ;

LAMBETH, JD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (33) :19465-19472