Oral contraceptives reduce lamotrigine plasma levels

被引：188
作者：
Sabers, A
Öhman, I
Christensen, J
Tomson, T
机构：
[1] Univ Aarhus, Danish Epilepsy Hosp, DK-8000 Aarhus C, Denmark
[2] Univ Aarhus, Dept Clin Pharmacol, DK-8000 Aarhus, Denmark
[3] Karolinska Hosp, Dept Clin Pharmacol, S-10401 Stockholm, Sweden
[4] Karolinska Hosp, Dept Neurol, S-10401 Stockholm, Sweden
来源：
NEUROLOGY | 2003年 / 61卷 / 04期
关键词：
D O I：
10.1212/01.WNL.0000076485.09353.7A
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The mean steady-state plasma concentration of lamotrigine (LTG) was 13 mumol/L in 22 women taking LTG in combination oral contraceptives (OC) compared with 28 mumol/L among 30 women on LTG who did not take OC ( p < 0.0001). The LTG dose/body weight/plasma concentration was 2.1 L/kg/day in women on OC compared with 0.8 L/kg/day in women without OC ( p < 0.0001), indicating that LTG plasma levels are reduced by > 50% during OC co-medication. It is advisable to monitor LTG plasma levels in conjunction with initiation or withdrawal of OC in women on LTG therapy.
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页码：570 / 571
页数：2
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