Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells

被引：22

作者：

Liu, Bin

Shi, Yufeng

Peng, Wending

Zhang, Qingyu

Liu, Jie

Chen, Nianping ^{[1
,2
]}

Zhu, Runzhi ^{[1
,2
]}

机构：

[1] Guangdong Med Univ, Lab Hepatobiliary Surg, 57 Renmin Rd, Zhanjiang 524001, Guangdong, Peoples R China

[2] Guangdong Med Univ, Zhanjiang Key Lab Hepatobiliary Dis, Affiliated Hosp, 57 Renmin Rd, Zhanjiang 524001, Guangdong, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2016年 / 14卷 / 01期

关键词：

diosmetin; TGF-beta; HepG2; apoptosis; HEPATOCELLULAR-CARCINOMA; FLAVONOIDS DIOSMETIN; ANTIOXIDANT ACTIVITY; NATURAL-PRODUCTS; PROGRESSION; METABOLISM; ACTIVATION;

D O I：

10.3892/mmr.2016.5258

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Diosmetin (Dio) is a major active component of flavonoid compounds. A previous study demonstrated that Dio exhibited anticancer activity and induced apoptosis in HepG2 human hepatoma cells via cytochrome P450, family 1-catalyzed metabolism. The present study observed that cell proliferation of HepG2 cells was inhibited by Dio treatment and tumor protein p53 was significantly increased following Dio treatment. Following addition of recombinant transforming growth factor-beta (TGF-beta) protein to Dio-treated HepG2 cells, cell growth inhibition and cell apoptosis was partially reversed. These findings suggest a novel function for the TGF-beta/TGF-beta receptor signaling pathway and that it may be a key target of Dio-induced cell apoptosis in HepG2 cells.

引用

收藏

页码：159 / 164

页数：6

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