Prioritizing agricultural pesticides to protect human health: A multi-level strategy combining life cycle impact and risk assessments

In this study, a multi-level strategy to prioritize pesticides for use in agriculture is proposed in support of pro-tecting human health. The strategy includes four levels (production, application, distribution, and bio-accumulation) of screening approaches, for which the life cycle impact assessment (LCIA) and human health risk assessment (HHRA) models were applied to generate priority lists at each level. The LCIA model was used at the production level (i.e., chemical design; before pesticides being registered and entering the market), providing the inventory management based on environmental persistence and toxicity potential of pesticides, whereas the HHRA models were used at the other three levels, assessing human health risks based on pesticide emission to cropland. Priority scores (PS) of 319 pesticides were simulated with high scores indicating high priority for use in agriculture (relatively high human safety). The simulated results via the LCIA at the production level had strong positive correlations with those via the HHRA at the other three levels, indicating that the LCIA tool was capable of an initial screening of pesticides for use in agriculture. The simulated PS values of 319 pesticides indicated that some pesticides (e.g., chlorpyrifos and fipronil) with low PS values (e.g., < 8) that are currently used in some countries should be further evaluated. For other pesticides with high simulated PS values (e.g., > 15) for use in agriculture, their ecotoxicity impacts and ecological risks should be considered in protecting human health.