A thiol-reactive fluorescence probe based on donor-excited photoinduced electron transfer: Key role of ortho substitution

被引：287

作者：

Matsumoto, Takuya ^{[1
]}

Urano, Yasuteru ^{[1
]}

Shoda, Takuji ^{[1
]}

Kojima, Hirotatsu ^{[1
]}

Nagano, Tetsuo ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 17期

关键词：

D O I：

10.1021/ol071352e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We designed and synthesized a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore. The fluorescence of this probe is strongly quenched by donor-excited photoinduced electron transfer (d-PeT) from BODIPY to maleimide, but after reaction with thiol, the fluorescence of BODIPY is restored, affording a 350-fold intensity increase.

引用

页码：3375 / 3377

页数：3

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