A thiol-reactive fluorescence probe based on donor-excited photoinduced electron transfer: Key role of ortho substitution

被引：284
作者：
Matsumoto, Takuya [1 ]
Urano, Yasuteru [1 ]
Shoda, Takuji [1 ]
Kojima, Hirotatsu [1 ]
Nagano, Tetsuo [1 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 17期
关键词：
D O I：
10.1021/ol071352e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We designed and synthesized a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore. The fluorescence of this probe is strongly quenched by donor-excited photoinduced electron transfer (d-PeT) from BODIPY to maleimide, but after reaction with thiol, the fluorescence of BODIPY is restored, affording a 350-fold intensity increase.
引用
收藏
页码：3375 / 3377
页数：3
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