Boron nitride nanotube reinforced polylactide-polycaprolactone copolymer composite: Mechanical properties and cytocompatibility with osteoblasts and macrophages in vitro

被引：215

作者：

Lahiri, Debrupa ^{[1
]}

Rouzaud, Francois

Richard, Tanisha ^{[1
]}

Keshri, Anup K. ^{[1
]}

Bakshi, Srinivasa R. ^{[1
]}

Kos, Lidia

Agarwal, Arvind ^{[1
]}

机构：

[1] Florida Int Univ, Miami, FL 33174 USA

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 09期

基金：

美国国家科学基金会;

关键词：

Biodegradable polymer composite; Boron nitride nanotube; Mechanical properties; Viability; Cytotoxicity; EPSILON-CAPROLACTONE; CARBON NANOTUBES; MOLECULAR-WEIGHT; ELASTIC-MODULUS; BONE-TISSUE; GLASS; PLA; DEGRADATION; FABRICATION; PROTEINS;

D O I：

10.1016/j.actbio.2010.02.044

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Biodegradable polylactide-polycaprolactone copolymer (PLC) has been reinforced with 0, 2 and 5 wt.% boron nitride nanotubes (BNNTs) for orthopedic scaffold application. Elastic modulus of the PLC-5 wt.% BNNT composite, evaluated through nanoindentation technique, shows a 1370% increase. The same amount of BNNT addition to PLC enhances the tensile strength by 109%, without any adverse effect on the ductility up to 240% elongation. Interactions of the osteoblasts and macrophages with bare BNNTs prove them to be non-cytotoxic. PLC-BNNT composites displayed increased osteoblast cell viability as compared to the PLC matrix. The addition of BNNTs also resulted in an increase in the expression levels of the Runx2 gene, the main regulator of osteoblast differentiation. These results indicate that BNNT is a potential reinforcement for composites for orthopedic applications. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：3524 / 3533

页数：10

共 70 条

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