porous MoS2 nanofiber;
pH and NIR responsive;
doxorubicin;
drug delivery;
cancer therapy;
ISOCARBOPHOS DEGRADING BACTERIUM;
DEGRADATION;
RELEASE;
NANOCARRIERS;
CHEMOTHERAPY;
NANOSHEETS;
THERAPY;
METHYL;
METAL;
DOTS;
D O I:
10.1088/1361-6528/ac0a18
中图分类号:
TB3 [工程材料学];
学科分类号:
0805 ;
080502 ;
摘要:
Porous MoS2 nanofibers were synthesized by electroplating and post-annealing and applied in a responsive drug delivery system. The one-dimensional (1D) MoS2 nanofibers displayed a high specific surface area, controllable morphology, and uniform size, serving as a promising drug carrier for chemotherapy. After surface modification with polyethylene glycol (PEG) through PEGylation, the MoS2/PEG composite displayed excellent physical/chemical stability and biocompatibility. More importantly, MoS2/PEG loaded with doxorubicin (DOX) exhibited a controllable release responsive to pH and near-infrared (NIR) irradiation and demonstrated precise DOX dose release. Such remarkable anticancer effects were mainly attributed to outstanding photothermal performance and stability of porous MoS2 nanofibers. This work offered a new opportunity of employing porous MoS2 nanofibers as drug carriers for effective cancer chemotherapy.
机构:
Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Li, Sheng
Zhang, Renzi
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机构:
Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Zhang, Renzi
Wang, Daoxin
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h-index: 0
机构:
Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Wang, Daoxin
Feng, Li
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Univ Technol, Sch Civil & Transportat Engn, Guangzhou 510006, Guangdong, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Feng, Li
Cui, Kang
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Univ, Dept Mat Sci, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
机构:
Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Li, Sheng
Zhang, Renzi
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Zhang, Renzi
Wang, Daoxin
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Wang, Daoxin
Feng, Li
论文数: 0引用数: 0
h-index: 0
机构:
Guangdong Univ Technol, Sch Civil & Transportat Engn, Guangzhou 510006, Guangdong, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China
Feng, Li
Cui, Kang
论文数: 0引用数: 0
h-index: 0
机构:
Chongqing Univ, Dept Mat Sci, Chongqing 400010, Peoples R ChinaChongqing Med Univ, Dept Resp & Crit Care Med, Affiliated Hosp 2, Chongqing 400010, Peoples R China