Synthesis of aminoalkylpyrazoles and -isoxazoles from cyclic β-(trifluoroacetyl) enamines

被引：10
|
作者：
Nenajdenko, V. G. [1 ]
Pronin, S. V. [1 ]
Balenkova, E. S. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 02期
关键词：
alpha; beta-enones; enamines; pyrazoles; isoxazoles; hydrazines; hydroxylamine; organofluorine compounds; heterocyclization;
D O I：
10.1007/s11172-007-0055-7
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method for the synthesis of cyclic beta-(trifluoroacetyl) enamines was proposed. Reactions of the latter with hydrazine and hydroxylamine gave pyrazoles and isoxazoles, respectively, containing trifluoromethyl and omega-aminoalkyl fragments. Addition of hydrazine (hydroxylamine) to the above amino enones was regiospecific, the regiochemistry of the heterocyclization of trifluoromethyl ketones being different from that for nonfluorinated analogs.
引用
收藏
页码：336 / 344
页数：9
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