Synthesis of aminoalkylpyrazoles and -isoxazoles from cyclic β-(trifluoroacetyl) enamines

被引：10

作者：

Nenajdenko, V. G. ^{[1
]}

Pronin, S. V. ^{[1
]}

Balenkova, E. S. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2007年 / 56卷 / 02期

关键词：

alpha; beta-enones; enamines; pyrazoles; isoxazoles; hydrazines; hydroxylamine; organofluorine compounds; heterocyclization;

D O I：

10.1007/s11172-007-0055-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A method for the synthesis of cyclic beta-(trifluoroacetyl) enamines was proposed. Reactions of the latter with hydrazine and hydroxylamine gave pyrazoles and isoxazoles, respectively, containing trifluoromethyl and omega-aminoalkyl fragments. Addition of hydrazine (hydroxylamine) to the above amino enones was regiospecific, the regiochemistry of the heterocyclization of trifluoromethyl ketones being different from that for nonfluorinated analogs.

引用

页码：336 / 344

页数：9

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