Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

被引：256

作者：

Hmadcha, Abdelkrim ^{[1
,2
]}

Martin-Montalvo, Alejandro ^{[1
]}

Gauthier, Benoit R. ^{[1
,2
]}

Soria, Bernat ^{[2
,3
,4
]}

Capilla-Gonzalez, Vivian ^{[1
]}

机构：

[1] Univ Seville, Pablo de Olavide Univ, CSIC, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Seville, Spain

[2] Inst Hlth Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain

[3] Miguel Hernandez Univ, Sch Med, Alicante, Spain

[4] Pablo de Olavide Univ, Seville, Spain

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2020年 / 8卷

关键词：

mesenchymal stem cells; cancer; cell therapy; therapeutic agents; anti-tumor activity; MARROW STROMAL CELLS; APOPTOSIS-INDUCING LIGAND; BONE-MARROW; TGF-BETA; ADIPOSE-TISSUE; MACROPHAGE-MIGRATION; PROMOTING MIGRATION; BRAIN-INJURY; DIFFERENTIATION; EXPRESS;

D O I：

10.3389/fbioe.2020.00043

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mesenchymal stem cells (MSCs) are among the most frequently used cell type for regenerative medicine. A large number of studies have shown the beneficial effects of MSC-based therapies to treat different pathologies, including neurological disorders, cardiac ischemia, diabetes, and bone and cartilage diseases. However, the therapeutic potential of MSCs in cancer is still controversial. While some studies indicate that MSCs may contribute to cancer pathogenesis, emerging data reported the suppressive effects of MSCs on cancer cells. Because of this reality, a sustained effort to understand when MSCs promote or suppress tumor development is needed before planning a MSC-based therapy for cancer. Herein, we provide an overview on the therapeutic application of MSCs for regenerative medicine and the processes that orchestrates tissue repair, with a special emphasis placed on cancer, including central nervous system tumors. Furthermore, we will discuss the current evidence regarding the double-edged sword of MSCs in oncological treatment and the latest advances in MSC-based anti-cancer agent delivery systems.

引用

页数：13

共 135 条

[121] MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2 [J].