Neutrophil Gelatinase-Associated Lipocalin as Potential Predictive Biomarker of Melanoma and Non-Melanoma Skin Cancers in Psoriatic Patients: A Pilot Study

被引：5

作者：

Verdelli, Alice ^{[1
]}

Caproni, Marzia ^{[1
]}

Coi, Alessio ^{[2
]}

Corra, Alberto ^{[3
]}

Degl'Innocenti, Donatella ^{[4
]}

Vasarri, Marzia ^{[4
]}

Quintarelli, Lavinia ^{[1
]}

Volpi, Valter ^{[1
]}

Cipollini, Emanuele Maria ^{[1
]}

Barletta, Emanuela ^{[4
]}

机构：

[1] Univ Florence, Azienda USL Toscana Ctr, Rare Dermatol Unit, Dept Hlth Sci,Sect Dermatol, I-50125 Florence, Italy

[2] CNR, Inst Clin Physiol, Unit Epidemiol Rare Dis & Congenital Anomalies, I-56127 Pisa, Italy

[3] Univ Florence, Dept Hlth Sci, Sect Dermatol, I-50125 Florence, Italy

[4] Univ Florence, Dept Expt & Clin Biomed Sci, Viale Morgagni 50, I-50134 Florence, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 20期

关键词：

human neutrophil gelatinase-associated lipocalin; lipocalin; psoriasis; skin cancers; non-melanoma skin cancers; melanoma; biomarkers; VITAMIN-D; CUTANEOUS MELANOMA; SERUM LIPOCALIN-2; RISK; NGAL; INFLAMMATION; ROLES; EXPRESSION; MARKERS; MATRIX;

D O I：

10.3390/ijms232012291

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Studies have demonstrated a higher risk of nonmelanoma skin cancers (NMSC) and a modestly increased melanoma risk in patients with psoriasis. To date, no biomarkers predictive of evolution have been identified yet. Methods: The aim of this prospective case-control study was to investigate the potential role of neutrophil gelatinase-associated lipocalin (NGAL) as a predictive biomarker of skin cancers in psoriatic patients. Patients with a diagnosis of psoriasis were enrolled, as well as healthy subjects and patients with skin cancers as controls. Plasma protein expression of NGAL, metalloproteinases (MMP)-2, and MMP-9 was performed by an enzyme-linked immunosorbent assay (ELISA). In all the patients who developed skin cancer at follow-up, NGAL, MMP-2, and MMP-9 serum levels were dosed again. Results: Plasma NGAL levels were significantly higher in psoriatic patients with NMSC than without (182.3 +/- 36.6 ng/mL vs. 139.9 +/- 39.3 ng/mL) (p < 0.001). Plasma NGAL levels were significantly higher (p < 0.00001) in patients with psoriasis and NMSC than in patients with skin tumors without psoriasis (182.3 vs. 122.9). Patients with psoriasis who developed NMSC at follow-up showed increased plasma MMP-9 levels. Conclusion: NGAL seems to play a role in the pathogenesis of NMSC but not melanoma in patients with psoriasis.

引用

页数：13

共 59 条

[1] Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination [J].