Identification of a cell population that produces alpha/beta interferon in vitro and in vivo in response to noncytopathic bovine viral diarrhea virus

被引：23

作者：

Brackenbury, LS ^{[1
]}

Carr, BV ^{[1
]}

Stamataki, Z ^{[1
]}

Prentice, H ^{[1
]}

Lefevre, EA ^{[1
]}

Howard, CJ ^{[1
]}

Charleston, B ^{[1
]}

机构：

[1] Inst Anim Hlth, Newbury RG20 7NN, Berks, England

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 12期

关键词：

D O I：

10.1128/JVI.79.12.7738-7744.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In vitro infection of bovine cells of many origins with the cytopathogenic bovine viral diarrhea virus (cpBVDV) results in the induction of alpha/beta interferon (IFN-alpha/beta), whereas noncytopathogenic BVDV (ncpBVDV) isolates have been shown not to induce IFN-alpha/beta in vitro. Similarly, epBVDV induces IFN-alpha/beta in the early bovine fetus, but ncpBVDV does not. However, acute infection of naive cattle with ncpBVDV results in IFN-alpha/beta production. In this study, we identified and characterized a minor population of cells, present in lymph nodes that produce IFN-alpha in response to ncpBVDV. These cells expressed the myeloid markers CD14, CD11b, and CD172a but did not express CD4 and CD45RB. We also established that these cells produced IFN-alpha in the absence of detectable productive infection.

引用

页码：7738 / 7744

页数：7

共 26 条

[1] Macrophages infected with cytopathic bovine viral diarrhea virus release a factor(s) capable of priming uninfected macrophages for activation-induced apoptosis [J].