Innate Immunity Protein IFITM3 in Alzheimer's Disease

被引：5

作者：

Hur, Ji-Yeun ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Chem Biol Program, New York, NY USA

来源：

DNA AND CELL BIOLOGY | 2021年 / 40卷 / 11期

关键词：

Alzheimer's disease; gamma-secretase; amyloid-beta; interferon-induced transmembrane protein 3; IFITM3; innate immunity; SIMPLEX-VIRUS TYPE-1; GAMMA-SECRETASE; GENES; RISK; PRESENILIN; DEMENTIA; DISTINCT; BINDING; BRAIN;

D O I：

10.1089/dna.2021.0585

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several genes in innate immunity have been implicated in Alzheimer's disease (AD). However, the effect of innate immunity on amyloid beta (A beta) production, which makes amyloid plaques in AD brains, was previously not known. Recently, the antiviral protein interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel gamma-secretase modulatory protein for A beta production. In this review, the mechanisms of how innate immunity modulates A beta production via IFITM3-gamma-secretase complexes and contributes to AD pathogenesis are discussed.

引用

页码：1351 / 1355

页数：5

共 48 条

[1] SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans [J].

Allen, E. Kaitlynn ;

Randolph, Adrienne G. ;

Bhangale, Tushar ;

Dogra, Pranay ;

Ohlson, Maikke ;

Oshansky, Christine M. ;

Zamora, Anthony E. ;

Shannon, John P. ;

Finkelstein, David ;

Dressen, Amy ;

DeVincenzo, John ;

Caniza, Miguela ;

Youngblood, Ben ;

Rosenberger, Carrie M. ;

Thomas, Paul G. .

NATURE MEDICINE, 2017, 23 (08) :975-+

[2] IFITM-Family Proteins: The Cell's First Line of Antiviral Defense [J].

Bailey, Charles C. ;

Zhong, Guocai ;

Huang, I-Chueh ;

Farzan, Michael .

ANNUAL REVIEW OF VIROLOGY, VOL 1, 2014, 1 :261-283

[3] Current status on Alzheimer disease molecular genetics: from past, to present, to future [J].

Bettens, Karolien ;

Sleegers, Kristel ;

Van Broeckhoven, Christine .

HUMAN MOLECULAR GENETICS, 2010, 19 :R4-R11

[4] Clinical and Bacterial Markers of Periodontitis and Their Association with Incident All-Cause and Alzheimer's Disease Dementia in a Large National Survey [J].

Beydoun, May A. ;

Beydoun, Hind A. ;

Hossain, Sharmin ;

El-Hajj, Ziad W. ;

Weiss, Jordan ;

Zonderman, Alan B. .

JOURNAL OF ALZHEIMERS DISEASE, 2020, 75 (01) :157-172

[5] Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease [J].

Coric, Vladimir ;

van Dyck, Christopher H. ;

Salloway, Stephen ;

Andreasen, Niels ;

Brody, Mark ;

Richter, Ralph W. ;

Soininen, Hilkka ;

Thein, Stephen ;

Shiovitz, Thomas ;

Pilcher, Gary ;

Colby, Susan ;

Rollin, Linda ;

Dockens, Randy ;

Pachai, Chahin ;

Portelius, Erik ;

Andreasson, Ulf ;

Blennow, Kaj ;

Soares, Holly ;

Albright, Charles ;

Feldman, Howard H. ;

Berman, Robert M. .

ARCHIVES OF NEUROLOGY, 2012, 69 (11) :1430-1440

[6] Development and Mechanism of γ-Secretase Modulators for Alzheimer's Disease [J].

Crump, Christina J. ;

Johnson, Douglas S. ;

Li, Yue-Ming .

BIOCHEMISTRY, 2013, 52 (19) :3197-3216

[7] BMS-708,163 Targets Presenilin and Lacks Notch-Sparing Activity [J].

Crump, Christina J. ;

Castro, Suita V. ;

Wang, Feng ;

Pozdnyakov, Nikolay ;

Ballard, T. Eric ;

Sisodia, Sangram S. ;

Bales, Kelly R. ;

Johnson, Douglas S. ;

Li, Yue-Ming .

BIOCHEMISTRY, 2012, 51 (37) :7209-7211

[8] The secretases: enzymes with therapeutic potential in Alzheimer disease [J].

De Strooper, Bart ;

Vassar, Robert ;

Golde, Todd .

NATURE REVIEWS NEUROLOGY, 2010, 6 (02) :99-107

[9] A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease [J].

Doody, Rachelle S. ;

Raman, Rema ;

Farlow, Martin ;

Iwatsubo, Takeshi ;

Vellas, Bruno ;

Joffe, Steven ;

Kieburtz, Karl ;

He, Feng ;

Sun, Xiaoying ;

Thomas, Ronald G. ;

Aisen, Paul S. ;

Siemers, Eric ;

Sethuraman, Gopalan ;

Mohs, Richard .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (04) :341-350

[10] Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease [J].

Dujardin, Simon ;

Commins, Caitlin ;

Lathuiliere, Aurelien ;

Beerepoot, Pieter ;

Fernandes, Analiese R. ;

Kamath, Tarun, V ;

De Los Santos, Mark B. ;

Klickstein, Naomi ;

Corjuc, Diana L. ;

Corjuc, Bianca T. ;

Dooley, Patrick M. ;

Viode, Arthur ;

Oakley, Derek H. ;

Moore, Benjamin D. ;

Mullin, Kristina ;

Jean-Gilles, Dinorah ;

Clark, Ryan ;

Atchison, Kevin ;

Moore, Renee ;

Chibnik, Lori B. ;

Tanzi, Rudolph E. ;

Frosch, Matthew P. ;

Serrano-Pozo, Alberto ;

Elwood, Fiona ;

Steen, Judith A. ;

Kennedy, Matthew E. ;

Hyman, Bradley T. .

NATURE MEDICINE, 2020, 26 (08) :1256-+

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