Current strategies to improve the safety of chimeric antigen receptor (CAR) modified T cells

被引：6

作者：

Yang, Qi-Yu ^{[1
]}

Yang, Jia-dan ^{[2
]}

Wang, Yong-Sheng ^{[1
]}

机构：

[1] Sichuan Univ, Dept Thorac Oncol, West China Hosp, 37 Guo Xue Xiang, Chengdu, Sichuan, Peoples R China

[2] Chongqing Med Univ, Dept Pharm, Affiliated Hosp 1, Chongqing, Peoples R China

来源：

IMMUNOLOGY LETTERS | 2017年 / 190卷

关键词：

Safety; Chimeric antigen receptors; T cells; MACROPHAGE ACTIVATION SYNDROME; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; CANCER REGRESSION; CLINICAL-TRIAL; THERAPY; CD4(+); GENE; CYTOTOXICITY; PERSISTENCE;

D O I：

10.1016/j.imlet.2017.08.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adoptive immunotherapy adopting chimeric antigen receptor (CAR) modified T cells has arisen attention as a hard-hitting therapy for numerous cancers. CARs are genetically engineered receptors that could stimulate tumor cytotoxicity once binding to the specific tumor epitopes. In spite of current noteworthy achievements in hematologic malignancies, the safety problems have aroused public awareness. In this review, we will focus on recent potential strategies to improve the security of CAR modified T cells.

引用

页码：201 / 205

页数：5

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