Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review

被引：57

作者：

Mottaghipisheh, Javad ^{[1
]}

Taghrir, Hadi ^{[2
]}

Dehsheikh, Anahita Boveiri ^{[3
]}

Zomorodian, Kamiar ^{[4
]}

Irajie, Cambyz ^{[5
]}

Sourestani, Mohammad Mahmoodi ^{[3
]}

Iraji, Aida ^{[6
,7
]}

机构：

[1] Univ Innsbruck, Ctr Mol Biosci CMBI, Inst Pharm Pharmacognosy, Innrain 80-82, A-6020 Innsbruck, Austria

[2] Shiraz Univ Med Sci, Fac Pharm, Dept Med Chem, Shiraz 7146864685, Iran

[3] Shahid Chamran Univ Ahvaz, Fac Agr, Dept Hort Sci, Ahvaz 6135743311, Iran

[4] Shiraz Univ Med Sci, Sch Med, Dept Med Mycol & Parasitol, Shiraz 1433671348, Iran

[5] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Shiraz 7134814336, Iran

[6] Shiraz Univ Med Sci, Cent Res Lab, Shiraz 7134814336, Iran

[7] Shiraz Univ Med Sci, Stem Cells Technol Res Ctr, Shiraz 7134814336, Iran

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 11期

关键词：

flavonoids; linarin; chemotaxonomy; phytochemistry; bioactivities; FLOS-CHRYSANTHEMI-INDICI; NF-KAPPA-B; CIRSIUM-JAPONICUM; IN-VITRO; LIQUID-CHROMATOGRAPHY; SIMULTANEOUS QUANTIFICATION; INFLAMMATORY RESPONSE; CHEMICAL-CONSTITUENTS; INHIBITORY-ACTIVITY; CYTOKINE PRODUCTION;

D O I：

10.3390/ph14111104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Many flavonoids, as eminent phenolic compounds, have been commercialized and consumed as dietary supplements due to their incredible human health benefits. In the present study, a bioactive flavone glycoside linarin (LN) was designated to comprehensively overview its phytochemical and biological properties. LN has been characterized abundantly in the Cirsium, Micromeria, and Buddleja species belonging to Asteraceae, Lamiaceae, and Scrophulariaceae families, respectively. Biological assessments exhibited promising activities of LN, particularly, the remedial effects on central nervous system (CNS) disorders, whereas the remarkable sleep enhancing and sedative effects as well as AChE (acetylcholinesterase) inhibitory activity were highlighted. Of note, LN has indicated promising anti osteoblast proliferation and differentiation, thus a bone formation effect. Further biological and pharmacological assessments of LN and its optimized semi-synthetic derivatives, specifically its therapeutic characteristics on osteoarthritis and osteoporosis, might lead to uncovering potential drug candidates.

引用

页数：21

共 137 条

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