Association of single nucleotide polymorphism rs3803662 with the risk of breast cancer

被引：13

作者：

Yang, Yuan ^{[1
,2
]}

Wang, Wenjing ^{[1
,3
]}

Liu, Guiyou ^{[4
]}

Yu, Yingcui ^{[5
]}

Liao, Mingzhi ^{[1
]}

机构：

[1] Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China

[2] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China

[3] Tongji Univ, East Hosp, Sch Med, Res Ctr Translat Med, Shanghai 200092, Peoples R China

[4] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150006, Heilongjiang, Peoples R China

[5] Northwest A&F Univ, Coll Nat Resources & Environm, Yangling, Shaanxi, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; GENETIC-VARIANTS; PREDISPOSITION; METAANALYSIS; ALLELES; WOMEN; MODEL; TNRC9; 2Q35;

D O I：

10.1038/srep29008

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Large scale association studies have identified the single nucleotide polymorphism rs3803662 associated with breast cancer risk. However, the sample size of most studies is too small. Here, we performed this meta-analysis to make the result more convincing. Relevant articles published up to 2016 were identified by searching the PubMed database. 13 studies, involving a total of 29405 participants, were included in the meta-analysis. Odds Ratios (ORs) with 95% confidence intervals (CIs) was calculated with random or fixed effects model. All data analyses were analyzed by Review Manger 5.3 software. In Caucasian subgroup: Dominant model (TT + CT vs CC): OR = 1.17 (1.06, 1.29), Recessive model (TT vs CT + CC): OR = 1.25 (1.13, 1.39) and Allele frequency (T vs C): OR = 1.15 (1.08, 1.22). The present meta-analysis suggests that rs3803662 polymorphism is significantly associated with breast cancer risk in Caucasian women, and we did not find the association in Asian women.

引用

页数：6

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