Functional genomics in osteoarthritis: Past, present, and future

被引：27

作者：

Steinberg, Julia ^{[1
]}

Zeggini, Eleftheria ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1HH, England

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 2016年 / 34卷 / 07期

基金：

英国惠康基金;

关键词：

osteoarthritis; functional genomics; gene expression; methylation; proteomics; MESENCHYMAL STEM-CELLS; WIDE DNA METHYLATION; GENE-EXPRESSION; CHONDROCYTES REVEALS; KNEE OSTEOARTHRITIS; DIFFERENTIAL PROTEOME; CANDIDATE GENES; SYNOVIAL-FLUID; CARTILAGE; BONE;

D O I：

10.1002/jor.23296

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Osteoarthritis (OA) is a common complex disease of high public health burden. OA is characterized by the degeneration of affected joints leading to pain and reduced mobility. Over the last few years, several studies have focused on the genomic changes underpinning OA. Here, we provide a comprehensive overview of genome-wide, non-hypothesis-driven functional genomics (methylation, gene, and protein expression) studies of knee and hip OA in humans. Individual studies have generally been limited in sample size and hence power, and have differed in their approaches; nonetheless, some common themes have started to emerge, notably the role played by biological processes related to the extracellular matrix, immune response, the WNT pathway, angiogenesis, and skeletal development. Larger-scale studies and streamlined, robust methodologies will be needed to further elucidate the biological etiology of OA going forward. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1105-1110, 2016.

引用

页码：1105 / 1110

页数：6

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