Identification and characterization of antioxidant and immune-stimulatory polysaccharides in flaxseed hull

被引：49

作者：

Biao, Yuan ^{[1
]}

Han Jiannan ^{[1
]}

Cheng Yaolan ^{[1
]}

Cheng Shujie ^{[1
]}

Huang Dechun ^{[1
]}

Mcclements, David Julian ^{[2
]}

Cao Chongjiang ^{[1
]}

机构：

[1] China Pharmaceut Univ, Coll Engn, Natl R&D Ctr Chinese Herbal Med Proc, Dept Food Qual & Safety, Nanjing 211198, Jiangsu, Peoples R China

[2] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

来源：

FOOD CHEMISTRY | 2020年 / 315卷

基金：

中国国家自然科学基金;

关键词：

Flaxseed; Polysaccharide; Immune-enhancing; MAPK; RAW264.7; MACROPHAGES; SIGNALING PATHWAYS; PLEUROTUS-ERYNGII; MAPK; PURIFICATION; INFLAMMATION; FIBER;

D O I：

10.1016/j.foodchem.2020.126266

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Flaxseeds are widely consumed for their desirable sensory attributes and health benefits. We focused on enhancing the sustainability and economic potential of flaxseeds by characterizing functional attributes of polysaccharides isolated from flaxseed hull residues. In particular, antioxidant and immune-stimulatory polysaccharides were isolated and purified from flaxseed hull. Infrared spectroscopy was used to identify the key functional groups. The polysaccharides were composed of mannose, rhamnose, galactose, glucose, galactose, xylose, arabinose, and fucose. In vitro studies showed certain flaxseed hull polysaccharide fractions exhibited strong antioxidant activities, increased nitric oxide levels, and enhanced the production of cytokines (TNF-alpha and IL-6). In the presence of 200 mu g/mL of one of these fractions, the levels of p-ERK, p-JNK, and p-p38 increased significantly by 1.8-, 9.0-, and 6.7-fold. These polysaccharide fractions may exhibit their immune-regulatory properties partly by modulating the MAPK pathway. The flaxseed hull polysaccharides identified have potential application as natural antioxidants and immune-enhancing nutraceuticals.

引用

页数：6

共 28 条

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