Cobalt-Catalyzed Fluoroallyllation of Carbonyls via C-C Activation of gem-Difluorocyclopropanes

被引：38

作者：

Ai, Yinan ^{[1
]}

Yang, Hanlin ^{[1
]}

Duan, Chunying ^{[1
]}

Li, Xingwei ^{[2
,3
]}

Yu, Songjie ^{[1
,2
]}

机构：

[1] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Liaoning, Peoples R China

[2] Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Shandong, Peoples R China

[3] Shaanxi Normal Univ SNNU, Sch Chem & Chem Engn, Xian 710062, Shaanxi, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 28期

关键词：

ALLYLIC SUBSTITUTION; FLUORINE; ALKYLATION;

D O I：

10.1021/acs.orglett.2c01821

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new Co-catalyzed sequential C-C and C-F activation of gem-difluorinated cyclopropanes (gem-FCPs) to form nucleophilic fluoroallylcobalt, followed by addition to aldehydes, is reported. The protocol features the regioselective cleavage of dual chemical bonds of readily available gem-FCPs to prepare easily separable linear (Z)- and (E)-fluorinated homoallylic alcohols with a broad scope. This discovery established a new strategy for the efficient transformation of gem-FCPs as well as the synthesis of challenging fluorinated homoallylic alcohols.

引用

页码：5051 / 5055

页数：5

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