The synthesis, NMR and X-ray analysis of tris(1-ethyl-2-isopropylimidazol-5-yl)phosphine gold(I)-2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside, a bifunctional auranofin analogue

被引：11

作者：

Bell, RA ^{[1
]}

Lock, CJL ^{[1
]}

Scholten, C ^{[1
]}

Valliant, JF ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

来源：

INORGANICA CHIMICA ACTA | 1998年 / 274卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

crystal structures; rheumatoid arthritis; gold complexes; trisimidazole phosphine complexes;

D O I：

10.1016/S0020-1693(97)06039-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A derivative of auranofin, a drug used in the treatment of rheumatoid arthritis, was synthesised and examined by NMR spectroscopy and X-ray crystallography. The derivative, which contains a trisimidazole phosphine, was designed to complex hard metals in addition to binding to the gold(I) centre. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：137 / 142

页数：6

共 18 条

[1]

BERGLOF FE, 1978, J RHEUMATOL, V5, P68

[2]

BROWN RS, 1982, J AM CHEM SOC, V104, P11

[3]

Cowan J. A., 1993, INORGANIC BIOCH INTR, P277

[4] AURANOFIN - NEW ORAL GOLD COMPOUND FOR TREATMENT OF RHEUMATOID-ARTHRITIS [J].