New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

被引：37

作者：

Bai, Zhi-Qiang ^{[1
,2
]}

Lin, Xiuping ^{[1
]}

Wang, Junfeng ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Liu, Juan ^{[1
]}

Yang, Bin ^{[1
]}

Yang, Xianwen ^{[1
]}

Liao, Shengrong ^{[1
]}

Wang, Lishu ^{[3
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

[3] Jilin Prov Acad Chinese Med Sci, Changchun 130021, Peoples R China

来源：

MARINE DRUGS | 2015年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

meroterpenoid; Aspergillus flavipes; endophytic fungus; ALTERNARIA-ALTERNATA; TRICYCLOALTERNARENE DERIVATIVES; MIXED TERPENOIDS; PEPTIDE DEFORMYLASE; INHIBITORY-ACTIVITY; ASPOCHALASIN; BICYCLOALTERNARENES; PRODUCTS; STRAIN; TOXINS;

D O I：

10.3390/md13010237

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1-7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.

引用

页码：237 / 248

页数：12

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