New Meroterpenoids from the Endophytic Fungus Aspergillus flavipes AIL8 Derived from the Mangrove Plant Acanthus ilicifolius

被引：37

作者：

Bai, Zhi-Qiang ^{[1
,2
]}

Lin, Xiuping ^{[1
]}

Wang, Junfeng ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Liu, Juan ^{[1
]}

Yang, Bin ^{[1
]}

Yang, Xianwen ^{[1
]}

Liao, Shengrong ^{[1
]}

Wang, Lishu ^{[3
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

[3] Jilin Prov Acad Chinese Med Sci, Changchun 130021, Peoples R China

来源：

MARINE DRUGS | 2015年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

meroterpenoid; Aspergillus flavipes; endophytic fungus; ALTERNARIA-ALTERNATA; TRICYCLOALTERNARENE DERIVATIVES; MIXED TERPENOIDS; PEPTIDE DEFORMYLASE; INHIBITORY-ACTIVITY; ASPOCHALASIN; BICYCLOALTERNARENES; PRODUCTS; STRAIN; TOXINS;

D O I：

10.3390/md13010237

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new meroterpenoids (2-5), along with three known analogues (1, 6, and 7) were isolated from mangrove plant Acanthus ilicifolius derived endophytic fungus Aspergillus flavipes. The structures of these compounds were elucidated by NMR and MS analysis, the configurations were assigned by CD data, and the stereochemistry of 1 was confirmed by X-ray crystallography analysis. A possible biogenetic pathway of compounds 1-7 was also proposed. All compounds were evaluated for antibacterial and cytotoxic activities.

引用

页码：237 / 248

页数：12

共 38 条

[1] New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius
Bai, Zhi-Qiang
Lin, Xiuping
Wang, Yizhu
Wang, Junfeng
Zhou, Xuefeng
Yang, Bin
Liu, Juan
Yang, Xianwen
Wang, Yi
Liu, Yonghong
[J]. FITOTERAPIA, 2014, 95 : 194 - 202
[2] SPIROQUINAZOLINE, A NOVEL SUBSTANCE-P INHIBITOR WITH A NEW CARBON SKELETON, ISOLATED FROM ASPERGILLUS FLAVIPES
BARROW, CJ
SUN, HH
[J]. JOURNAL OF NATURAL PRODUCTS, 1994, 57 (04): : 471 - 476
[3] Blunt JW, 2014, NAT PROD REP, V31, P160, DOI [10.1039/c7np00052a, 10.1039/c3np70117d]
[4] CASINOVI CG, 1968, TETRAHEDRON LETT, P3175
[5] FLAVIPUCINE [3'-ISOVALERYL-6-METHYLPYRIDINE-3-SPIRO-2'-OXIRAN-2(1H),-4(3H)-DIONE],AN ANTIBIOTIC FROM ASPERGILLUS-FLAVIPES
FINDLAY, JA
RADICS, L
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (16): : 2071 - +
[6] New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp SCSIO 05240
Fredimoses, Mangaladoss
Zhou, Xuefeng
Lin, Xiuping
Tian, Xinpeng
Ai, Wen
Wang, Junfeng
Liao, Shengrong
Liu, Juan
Yang, Bin
Yang, Xianwen
Liu, Yonghong
[J]. MARINE DRUGS, 2014, 12 (06): : 3190 - 3202
[7] Meroterpenes isolated from the endophytic fungus Guignardia mangiferae
Guimaraes, Denise O.
Lopes, Norberto P.
Pupo, Monica T.
[J]. PHYTOCHEMISTRY LETTERS, 2012, 5 (03) : 519 - 523
[8] Cerebroside analogues from marine-derived fungus Aspergillus flavipes
Jiang, T
Li, T
Li, J
Fu, HZ
Pei, YH
Lin, WH
[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2004, 6 (04) : 249 - 257
[9] Methods for isolation of marine-derived endophytic fungi and their bioactive secondary products
Kjer, Julia
Debbab, Abdessamad
Aly, Amal H.
Proksch, Peter
[J]. NATURE PROTOCOLS, 2010, 5 (03) : 479 - 490
[10] TMC-169, a new antibiotic of the aspochalasin group produced by Aspergillus flavipes
Kohno, J
Nonaka, N
Nishio, M
Ohnuki, T
Kawano, K
Okuda, T
Komatsubara, S
[J]. JOURNAL OF ANTIBIOTICS, 1999, 52 (06) : 575 - 577

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