Selective Palladium(II)-Catalyzed Carbonylation of Methylene β-C-H Bonds in Aliphatic Amines

被引：87

作者：

Cabrera-Pardo, Jaime R. ^{[1
]}

Trowbridge, Aaron ^{[1
]}

Nappi, Manuel ^{[1
]}

Ozaki, Kyohei ^{[1
]}

Gaunt, Matthew J. ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 39期

基金：

英国工程与自然科学研究理事会;

关键词：

aliphatic amines; carbonylation; C-H activation; lactams; palladium catalysis; UNACTIVATED C(SP(3))-H BONDS; TRANSIENT DIRECTING GROUP; GAMMA-LACTAMS; ARYLATION; ACTIVATION; LIGAND; FUNCTIONALIZATION; ACIDS; OLEFINATION; OXIDATION;

D O I：

10.1002/anie.201706303

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Palladium(II)-catalyzed C-H carbonylation reactions of methylene C-H bonds in secondary aliphatic amines lead to the formation of trans-disubstituted beta-lactams in excellent yields and selectivities. The generality of the C-H carbonylation process is aided by the action of xantphos-based ligands and is important in securing good yields for the beta-lactam products.

引用

页码：11958 / 11962

页数：5

共 61 条

[1] β-lactams:: Versatile building blocks for the stereoselective synthesis of non-β-lactam products [J].