An efficient synthesis of quinazoline derivatives with the aid of low-valent titanium reagent

被引：46

作者：

Shi, DQ ^{[1
]}

Shi, CL ^{[1
]}

Wang, JX ^{[1
]}

Rong, LC ^{[1
]}

Zhuang, QY ^{[1
]}

Wang, XS ^{[1
]}

机构：

[1] Xuzhou Normal Univ, Dept Chem, Key Lab Biotechnol Med Plant Jiangsu Prov, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2005年 / 42卷 / 02期

关键词：

D O I：

10.1002/jhet.5570420201

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinazolin-4(3H)-ones, 1,2-dihydroquinazolin-4(3H)-ones, 3,4-dihydroquinazolines, imidazo[1,2-c]quinazolines and 5,6-dihydroimidazo[1,2-c]quinazolines were synthesized by the novel reductive reaction of nitro group, N-H bond and ortho-ester, aldehydes or ketones promoted by the low-valent titanium reagent (TiCl4-Zn system). The structures of these compounds were characterized by elemental analysis, IR and (HNMR)-H-1 spectra and further confirmed by single crystal X-ray diffraction analysis.

引用

页码：173 / 183

页数：11

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