Metal-mediate reactions based formal synthesis of triptonide and triptolide

被引：15

作者：

Xu, Hongtao ^{[1
]}

Tang, Huanyu ^{[1
]}

Feng, Huijin ^{[1
]}

Li, Yuanchao ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 51期

关键词：

Diterpenoid; Triptolide; Triptonide; Metal; Synthesis; PALLADIUM-CATALYZED CARBONYLATION; ASYMMETRIC TRANSFER HYDROGENATION; TRIPTERYGIUM-WILFORDII; KETONES; (-)-TRIPTOLIDE; ACID; OXYGENATION; LACTONES; DESIGN; ACCESS;

D O I：

10.1016/j.tetlet.2014.11.010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A formal synthesis of triptolide and triptonide has been achieved based on metal-mediate reactions. Specially, Noyori's ruthenium catalyzed enantioselective transfer hydrogenation, indium(III) catalyzed cationic polyene cyclization, palladium catalyzed carbonylation, rhodium catalyzed double bond migration, and palladium catalyzed ortho sp(2) C-H bond oxygenation reactions served as convenient entry points for the preparation of the tetracyclic building blocks and the C14 hydroxyl group. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：7118 / 7120

页数：3

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