Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018-2019 Influenza Season

被引：29

作者：

Sato, Masatoki ^{[1
]}

Takashita, Emi ^{[2
]}

Katayose, Masahiko ^{[3
]}

Nemoto, Kenji ^{[4
]}

Sakai, Nobuko ^{[5
]}

Hashimoto, Koichi ^{[1
]}

Hosoya, Mitsuaki ^{[1
]}

机构：

[1] Fukushima Med Univ, Dept Pediat, 1 Hikarigaoka, Fukushima 9601295, Japan

[2] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo, Japan

[3] Nanohana Kids Clin, Soma, Japan

[4] Nemoto Kids Clin, Shirakawa, Japan

[5] Jin Kids Clin, Koriyama, Fukushima, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 01期

基金：

日本学术振兴会;

关键词：

antiviraltherapy; baloxavir; influenza; oseltamivir; resistance; ADULTS;

D O I：

10.1093/infdis/jiaa061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the 2018-2019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus ribonucleic acid polymerase in 7 of 18 baloxavi-treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants. The emergence of these variants should be monitored during future influenza seasons.

引用

页码：121 / 125

页数：5

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