Detection of Variants With Reduced Baloxavir Marboxil Susceptibility After Treatment of Children With Influenza A During the 2018-2019 Influenza Season

被引：27

作者：

Sato, Masatoki ^{[1
]}

Takashita, Emi ^{[2
]}

Katayose, Masahiko ^{[3
]}

Nemoto, Kenji ^{[4
]}

Sakai, Nobuko ^{[5
]}

Hashimoto, Koichi ^{[1
]}

Hosoya, Mitsuaki ^{[1
]}

机构：

[1] Fukushima Med Univ, Dept Pediat, 1 Hikarigaoka, Fukushima 9601295, Japan

[2] Natl Inst Infect Dis, Influenza Virus Res Ctr, Tokyo, Japan

[3] Nanohana Kids Clin, Soma, Japan

[4] Nemoto Kids Clin, Shirakawa, Japan

[5] Jin Kids Clin, Koriyama, Fukushima, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 01期

基金：

日本学术振兴会;

关键词：

antiviraltherapy; baloxavir; influenza; oseltamivir; resistance; ADULTS;

D O I：

10.1093/infdis/jiaa061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the 2018-2019 influenza seasons, we detected reduced baloxavir marboxil (baloxavir) susceptible variants with I38S or I38T amino acid substitutions on the PA subunit of influenza virus ribonucleic acid polymerase in 7 of 18 baloxavi-treated children and found that virus titer rebounded in some of these children with variants. We also found fever durations to be similar between patients with or without the variants, but the patients with variants shed the virus 3 days longer and took longer to improve clinical symptoms than those without variants. The emergence of these variants should be monitored during future influenza seasons.

引用

页码：121 / 125

页数：5

共 50 条

[1] Detection of Variants With Reduced Baloxavir Marboxil and Oseltamivir Susceptibility in Children With Influenza A During the 2019-2020 Influenza Season [J].

Sato, Masatoki ;

Takashita, Emi ;

Katayose, Masahiko ;

Nemoto, Kenji ;

Sakai, Nobuko ;

Fujisaki, Seiichiro ;

Hashimoto, Koichi ;

Hosoya, Mitsuaki .

JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (10) :1735-1741

[2] Duration of fever and symptoms in children after treatment with baloxavir marboxil and oseltamivir during the 2018-2019 season and detection of variant influenza a viruses with polymerase acidic subunit substitutions [J].

Saito, Reiko ;

Osada, Hidekazu ;

Wagatsuma, Keita ;

Chon, Irina ;

Sato, Isamu ;

Kawashima, Takashi ;

Saito, Tadashi ;

Kodo, Naoki ;

Ono, Yasuhiko ;

Shimada, Yasushi ;

Phyu, WintWint ;

Shobugawa, Yugo .

ANTIVIRAL RESEARCH, 2020, 183

[3] Association Between Baloxavir Marboxil Prescription for Children with Influenza B Infections and Short-Term Healthcare Consumption in Japan During the 2018-2019 Influenza Season [J].

Shinno, Kazuma ;

Takeuchi, Masato ;

Kawakami, Koji .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2022, 11 (07) :310-315

[4] Effects of Influenza Vaccination in the United States During the 2018-2019 Influenza Season [J].

Chung, Jessie R. ;

Rolfes, Melissa A. ;

Flannery, Brendan ;

Prasad, Pragati ;

O'Halloran, Alissa ;

Garg, Shikha ;

Fry, Alicia M. ;

Singleton, James A. ;

Patel, Manish ;

Reed, Carrie .

CLINICAL INFECTIOUS DISEASES, 2020, 71 (08) :E368-E376

[5] Oseltamivir Treatment for Influenza During the Flu Season of 2018-2019: A Longitudinal Study [J].

Li, Xiao-Guang ;

Chen, Jing ;

Wang, Wei ;

Lin, Fei ;

Li, Lu ;

Liang, Jing-Jin ;

Deng, Zhong-Hua ;

Zhang, Bi-Ying ;

Jia, Ying ;

Su, Yuan-Bo ;

Kang, Yong-Feng ;

Du, Juan ;

Liu, Ya-Qiong ;

Xu, Jie ;

Lu, Qing-Bin .

FRONTIERS IN MICROBIOLOGY, 2022, 13

[6] Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012-2018 [J].

Koszalka, Paulina ;

Tilmanis, Danielle ;

Roe, Merryn ;

Vijaykrishna, Dhanasekaran ;

Hurt, Aeron C. .

ANTIVIRAL RESEARCH, 2019, 164 :91-96

[7] Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil [J].

Omoto, Shinya ;

Speranzini, Valentina ;

Hashimoto, Takashi ;

Noshi, Takeshi ;

Yamaguchi, Hiroto ;

Kawai, Makoto ;

Kawaguchi, Keiko ;

Uehara, Takeki ;

Shishido, Takao ;

Naito, Akira ;

Cusack, Stephen .

SCIENTIFIC REPORTS, 2018, 8

[8] Characterization of contemporary influenza B recombinant viruses harboring mutations of reduced susceptibility to baloxavir marboxil, in vitro and in mice [J].

Abed, Yacine ;

Fage, Clement ;

Checkmahomed, Liva ;

Venable, Marie-Christine ;

Boivin, Guy .

ANTIVIRAL RESEARCH, 2020, 179

[9] Duration of fever and symptoms in influenza-infected children treated with baloxavir marboxil during the 2019-2020 season in Japan and detection of influenza virus with the PA E23K substitution [J].

Wagatsuma, Keita ;

Saito, Reiko ;

Chon, Irina ;

Phyu, Wint Wint ;

Fujio, Kakuya ;

Kawashima, Takashi ;

Sato, Isamu ;

Saito, Tadashi ;

Minato, Michiyoshi ;

Kodo, Naoki ;

Suzuki, Eitaro ;

Ono, Yasuhiko ;

Masaki, Hironori ;

Shirahige, Yutaka ;

Kitano, Akito ;

Hamabata, Hirotsune ;

Sun Yuyang ;

Li Jiaming ;

Watanabe, Hisami .

ANTIVIRAL RESEARCH, 2022, 201

[10] Sensitivity of Commercially Available Influenza Rapid Diagnostic Tests in the 2018-2019 Influenza Season [J].

Sakai-Tagawa, Yuko ;

Yamayoshi, Seiya ;

Kawaoka, Yoshihiro .

FRONTIERS IN MICROBIOLOGY, 2019, 10

← 1 2 3 4 5 →