Reproducibility of brain dopamine transporter binding with Tc-99m TRODAT-1 SPECT in healthy young men

被引：6

作者：

Yeh, Chin-Bin ^{[2
]}

Chou, Yuan-Hwa ^{[3
,4
]}

Cheng, Cheng-Yi ^{[1
]}

Lee, Meei-Shyuan ^{[5
]}

Wang, Jhi-Joung ^{[6
]}

Lee, Chiang-Hsuan ^{[6
]}

Shiue, Chyng-Yann ^{[1
]}

Su, Tung-Ping ^{[3
,4
]}

Huang, Wen-Sheng ^{[1
,7
]}

机构：

[1] Triserv Gen Hosp, Dept Nucl Med, Taipei 114, Taiwan

[2] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan

[4] Natl Yang Ming Univ, Taipei 112, Taiwan

[5] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan

[6] Chi Mei Med Ctr, Dept Nucl Med, Tainan, Taiwan

[7] Cardinal Tien Hosp, Dept Nucl Med, Taipei, Taiwan

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2012年 / 201卷 / 03期

关键词：

Reproducibility; Dopamine transporter; Tc-99m-TRODAT-1; POSITRON-EMISSION-TOMOGRAPHY; PARKINSONS-DISEASE; TC-99M-TRODAT-1; SPECT; CLINICAL-DIAGNOSIS;

D O I：

10.1016/j.pscychresns.2011.07.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Single photon emission computed tomography (SPECT) with Tc-99m TRODAT-1 as ligand can be used to evaluate striatal dopamine transporters (DAT) in young subjects. The purpose of this study was to evaluate the reproducibility of Tc-99m-TRODAT-1 SPECT in DAT binding in healthy young men. Fourteen healthy young men were recruited. The test-retest studies were performed 1 week apart. Specific uptake ratios (SUR) of the striatum (ST) and its subregions, the caudate (CA) and the putamen (PU), were measured using the occipital cortex as the reference tissue. The reliability of the two measurements between test and retest, showed significant correlations for the ST. CA and PU, was demonstrated by calculating the intraclass correlation coefficient (ICC). Thus, Tc-99m-TRODAT-1 SPECT might provide a reproducible and reliable tool in clinical management of young patients with DAT-related disorders. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：222 / 225

页数：4

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