APOBEC3: Friend or Foe in Human Papillomavirus Infection and Oncogenesis?

被引：26

作者：

Warren, Cody J. ^{[1
]}

Santiago, Mario L. ^{[2
]}

Pyeon, Dohun ^{[3
]}

机构：

[1] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA

[2] Univ Colorado, Dept Med, Div Infect Dis, Anschutz Med Campus, Aurora, CO 80045 USA

[3] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA

来源：

ANNUAL REVIEW OF VIROLOGY | 2022年 / 9卷

基金：

美国国家卫生研究院;

关键词：

DNA CYTOSINE DEAMINASE; CYTIDINE DEAMINASES; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; MUTATIONAL SIGNATURES; DELETION POLYMORPHISM; SOMATIC MUTATIONS; UP-REGULATION; MUTAGENESIS; EXPRESSION;

D O I：

10.1146/annurev-virology-092920-030354

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human papillomavirus (HPV) infection is a causative agent of multiple human cancers, including cervical and head and neck cancers. In these HPV-positive tumors, somatic mutations are caused by aberrant activation of DNA mutators such as members of the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) family of cytidine deaminases. APOBEC3 proteins are most notable for their restriction of various viruses, including anti-HPV activity. However, the potential role of APOBEC3 proteins in HPV-induced cancer progression has recently garnered significant attention. Ongoing research stems from the observations that elevated APOBEC3 expression is driven by HPV oncogene expression and that APOBEC3 activity is likely a significant contributor to somatic mutagenesis in HPV-positive cancers. This review focuses on recent advances in the study of APOBEC3 proteins and their roles in HPV infection and HPV-driven oncogenesis. Further, we discuss critical gaps and unanswered questions in our understanding of APOBEC3 in virus-associated cancers.

引用

页码：375 / 395

页数：21

共 150 条

[71] APOBEC3 Multimerization Correlates with HIV-1 Packaging and Restriction Activity in Living Cells [J].

Li, Jinhui ;

Chen, Yan ;

Li, Ming ;

Carpenter, Michael A. ;

McDougle, Rebecca M. ;

Luengas, Elizabeth M. ;

Macdonald, Patrick J. ;

Harris, Reuben S. ;

Mueller, Joachim D. .

JOURNAL OF MOLECULAR BIOLOGY, 2014, 426 (06) :1296-1307

[72] APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL [J].

Li, Z. ;

Abraham, B. J. ;

Berezovskaya, A. ;

Farah, N. ;

Liu, Y. ;

Leon, T. ;

Fielding, A. ;

Tan, S. H. ;

Sanda, T. ;

Weintraub, A. S. ;

Li, B. ;

Shen, S. ;

Zhang, J. ;

Mansour, M. R. ;

Young, R. A. ;

Look, A. T. .

LEUKEMIA, 2017, 31 (10) :2057-2064

[73] An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer [J].

Lindskrog, Sia Viborg ;

Prip, Frederik ;

Lamy, Philippe ;

Taber, Ann ;

Groeneveld, Clarice S. ;

Birkenkamp-Demtroder, Karin ;

Jensen, Jorgen Bjerggaard ;

Strandgaard, Trine ;

Nordentoft, Iver ;

Christensen, Emil ;

Sokac, Mateo ;

Birkbak, Nicolai J. ;

Maretty, Lasse ;

Hermann, Gregers G. ;

Petersen, Astrid C. ;

Weyerer, Veronika ;

Grimm, Marc-Oliver ;

Horstmann, Marcus ;

Sjodahl, Gottfrid ;

Hoglund, Mattias ;

Steiniche, Torben ;

Mogensen, Karin ;

de Reynies, Aurelien ;

Nawroth, Roman ;

Jordan, Brian ;

Lin, Xiaoqi ;

Dragicevic, Dejan ;

Ward, Douglas G. ;

Goel, Anshita ;

Hurst, Carolyn D. ;

Raman, Jay D. ;

Warrick, Joshua, I ;

Segersten, Ulrika ;

Sikic, Danijel ;

van Kessel, Kim E. M. ;

Maurer, Tobias ;

Meeks, Joshua J. ;

DeGraff, David J. ;

Bryan, Richard T. ;

Knowles, Margaret A. ;

Simic, Tatjana ;

Hartmann, Arndt ;

Zwarthoff, Ellen C. ;

Malmstrom, Per-Uno ;

Malats, Nuria ;

Real, Francisco X. ;

Dyrskjot, Lars .

NATURE COMMUNICATIONS, 2021, 12 (01)

[74] A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity [J].

Logue, Eric C. ;

Bloch, Nicolin ;

Dhuey, Erica ;

Zhang, Ruonan ;

Cao, Ping ;

Herate, Cecile ;

Chauveau, Lise ;

Hubbard, Stevan R. ;

Landau, Nathaniel R. .

PLOS ONE, 2014, 9 (05)

[75] A Common Deletion in the APOBEC3 Genes and Breast Cancer Risk [J].

Long, Jirong ;

Delahanty, Ryan J. ;

Li, Guoliang ;

Gao, Yu-Tang ;

Lu, Wei ;

Cai, Qiuyin ;

Xiang, Yong-Bing ;

Li, Chun ;

Ji, Bu-Tian ;

Zheng, Ying ;

Ali, Simak ;

Shu, Xiao-Ou ;

Zheng, Wei .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (08) :573-579

[76] Upregulation of the APOBEC3 Family Is Associated with a Poor Prognosis and Influences Treatment Response to Raf Inhibitors in Low Grade Glioma [J].

Luo, Cheng ;

Wang, Songmao ;

Liao, Weijie ;

Zhang, Shikuan ;

Xu, Naihan ;

Xie, Weidong ;

Zhang, Yaou .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (19)

[77] High burden and pervasive positive selection of somatic mutations in normal human skin [J].

Martincorena, Inigo ;

Roshan, Amit ;

Gerstung, Moritz ;

Ellis, Peter ;

Van Loo, Peter ;

McLaren, Stuart ;

Wedge, David C. ;

Fullam, Anthony ;

Alexandrov, Ludmil B. ;

Tubio, Jose M. ;

Stebbings, Lucy ;

Menzies, Andrew ;

Widaa, Sara ;

Stratton, Michael R. ;

Jones, Philip H. ;

Campbell, Peter J. .

SCIENCE, 2015, 348 (6237) :880-886

[78] Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesviruses [J].

Martinez, Teresa ;

Shapiro, Maxwell ;

Bhaduri-McIntosh, Sumita ;

MacCarthy, Thomas .

VIRUS EVOLUTION, 2019, 5 (01)

[79] Distinct immune evasion inAPOBEC-enriched,HPV-negativeHNSCC [J].

Messerschmidt, Clemens ;

Obermayer, Benedikt ;

Klinghammer, Konrad ;

Ochsenreither, Sebastian ;

Treue, Denise ;

Stenzinger, Albrecht ;

Glimm, Hanno ;

Froehling, Stefan ;

Kindler, Thomas ;

Brandts, Christian H. ;

Schulze-Osthoff, Klaus ;

Weichert, Wilko ;

Tinhofer, Ingeborg ;

Klauschen, Frederick ;

Keilholz, Ulrich ;

Beule, Dieter ;

Rieke, Damian T. .

INTERNATIONAL JOURNAL OF CANCER, 2020, 147 (08) :2293-2302

[80] HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis [J].

Mirabello, Lisa ;

Yeager, Meredith ;

Yu, Kai ;

Clifford, Gary M. ;

Xiao, Yanzi ;

Zhu, Bin ;

Cullen, Michael ;

Boland, Joseph F. ;

Wentzensen, Nicolas ;

Nelson, Chase W. ;

Raine-Bennett, Tina ;

Chen, Zigui ;

Bass, Sara ;

Song, Lei ;

Yang, Qi ;

Steinberg, Mia ;

Burdett, Laurie ;

Dean, Michael ;

Roberson, David ;

Mitchell, Jason ;

Lorey, Thomas ;

Franceschi, Silvia ;

Castle, Philip E. ;

Walker, Joan ;

Zuna, Rosemary ;

Kreimer, Aimee R. ;

Beachler, Daniel C. ;

Hildesheim, Allan ;

Gonzalez, Paula ;

Porras, Carolina ;

Burk, Robert D. ;

Schiffman, Mark .

CELL, 2017, 170 (06) :1164-1174

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