Antiplatelet and invasive treatment in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency and acute coronary syndrome. The safety of aspirin

被引：7
作者：
Kafkas, N. V. [1 ]
Liakos, C. I. [1 ]
Mouzarou, G. [1 ]
机构：
[1] KAT Gen Hosp Att, Dept Cardiol, Athens 14561, Greece
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2015年 / 40卷 / 03期
关键词：
acetylsalicylic acid; acute coronary syndromes; angioplasty; aspirin; favism; Glucose-6-phosphate dehydrogenase (G6PD) deficiency;
D O I：
10.1111/jcpt.12262
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What is known and objective: Aspirin is an important drug in acute coronary syndromes (ACS) and percutaneous coronary interventions (PCI). However, its use is contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk for haemolytic anaemia). We report the management of 2 patients with class II G6PD deficiency and non-ST-segment elevation ACS (NSTE-ACS). Case description: The two patients were safely and efficiently treated with dual antiplatelet treatment (DAPT, aspirin plus ticagrelor) and PCI using new-generation drug-eluting stent (DES) despite G6PD deficiency. What is new and conclusion: NSTE-ACS management with DAPT and DES is probably safe and effective in class II G6PD-deficient patients.
引用
收藏
页码：349 / 352
页数：4
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