Antiplatelet and invasive treatment in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency and acute coronary syndrome. The safety of aspirin

被引：7
作者：
Kafkas, N. V. [1 ]
Liakos, C. I. [1 ]
Mouzarou, G. [1 ]
机构：
[1] KAT Gen Hosp Att, Dept Cardiol, Athens 14561, Greece
来源：
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2015年 / 40卷 / 03期
关键词：
acetylsalicylic acid; acute coronary syndromes; angioplasty; aspirin; favism; Glucose-6-phosphate dehydrogenase (G6PD) deficiency;
D O I：
10.1111/jcpt.12262
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
What is known and objective: Aspirin is an important drug in acute coronary syndromes (ACS) and percutaneous coronary interventions (PCI). However, its use is contraindicated in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk for haemolytic anaemia). We report the management of 2 patients with class II G6PD deficiency and non-ST-segment elevation ACS (NSTE-ACS). Case description: The two patients were safely and efficiently treated with dual antiplatelet treatment (DAPT, aspirin plus ticagrelor) and PCI using new-generation drug-eluting stent (DES) despite G6PD deficiency. What is new and conclusion: NSTE-ACS management with DAPT and DES is probably safe and effective in class II G6PD-deficient patients.
引用
收藏
页码：349 / 352
页数：4
相关论文
共 13 条
[1]   Glucose-6-phosphate dehydrogenase deficiency: a historical perspective [J].
Beutler, Ernest .
BLOOD, 2008, 111 (01) :16-24
[2]   Gluclose-6-phosphate dehydrogenase deficiency [J].
Cappellini, M. D. ;
Fiorelli, G. .
LANCET, 2008, 371 (9606) :64-74
[3]  
Christou A, 2011, HELL J CARDIOL, V52, P307
[4]   ASPIRIN AND GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY [J].
COLONNA, P .
BRITISH MEDICAL JOURNAL, 1981, 283 (6300) :1189-1189
[5]   ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J].
Hamm, Christian W. ;
Bassand, Jean-Pierre ;
Agewall, Stefan ;
Bax, Jeroen ;
Boersma, Eric ;
Bueno, Hector ;
Caso, Pio ;
Dudek, Dariusz ;
Gielen, Stephan ;
Huber, Kurt ;
Ohman, Magnus ;
Petrie, Mark C. ;
Sonntag, Frank ;
Uva, Miguel Sousa ;
Storey, Robert F. ;
Wijns, William ;
Zahger, Doron .
EUROPEAN HEART JOURNAL, 2011, 32 (23) :2999-3054
[6]   G6PD deficiency: the genotype-phenotype association [J].
Mason, Philip J. ;
Bautista, Jose M. ;
Gilsanz, Florinda .
BLOOD REVIEWS, 2007, 21 (05) :267-283
[7]  
MELONI T, 1989, ACTA HAEMATOL-BASEL, V81, P208
[8]   Glucose-6-phosphate Dehydrogenase Laboratory Assay: How, When, and Why? [J].
Minucci, Angelo ;
Giardina, Bruno ;
Zuppi, Cecilia ;
Capoluongo, Ettore .
IUBMB LIFE, 2009, 61 (01) :27-34
[9]   Glucose-6-Phosphate Dehydrogenase (G6PDH) Deficiency in a Patient with ST-Segment Elevation Acute Myocardial Infarction Successfully Treated by Simple Thrombectomy [J].
Porto, Italo ;
Leo, Andrea ;
Crea, Filippo .
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2011, 18 (05) :425-430
[10]   Drug-eluting stents in a patient with favism: is the aspirin administration safe? [J].
Rigattieri, Stefano ;
Silvestri, Pasquale ;
Minucci, Angelo ;
Di Russo, Cristian ;
Ferraiuolo, Giuseppe ;
Giardina, Bruno ;
Capoluongo, Ettore ;
Loschiavo, Paolo .
JOURNAL OF CARDIOVASCULAR MEDICINE, 2008, 9 (11) :1159-1162
12