Nano-gold assisted highly conducting and biocompatible bacterial cellulose-PEDOT:PSS films for biology-device interface applications

被引：57
作者：
Khan, Shaukat [1 ]
Ul-Islam, Mazhar [2 ]
Ullah, Muhammad Wajid [1 ,3 ]
Israr, Muhammad [1 ]
Jang, Jae Hyun [1 ]
Park, Joong Kon [1 ]
机构：
[1] Kyungpook Natl Univ, Dept Chem Engn, Taegu 702701, South Korea
[2] Dhofar Univ, Coll Engn, Dept Chem Engn, Salalah, Oman
[3] Huazhong Univ Sci & Technol, Dept Biomed Engn, Wuhan 430074, Hubei, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 107卷
基金：
新加坡国家研究基金会;
关键词：
Bacterial cellulose; Gold nanoparticles; Pedot:pss; Nanocomposites; Biocompatibility; Electrical conductivity; NANOPARTICLES; NANOCOMPOSITES; COMPOSITES; POLYPYRROLE; HYDROGEL; THERAPY;
D O I：
10.1016/j.ijbiomac.2017.09.064
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study reports the fabrication of highly conducting and biocompatible bacterial cellulose (BC)-gold nanopartides (AuNPs)-poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) (BC-AuNPs-PEDOT:PSS) composites for biology-device interface applications. The composites were fabricated using ex situ incorporation of AuNPs and PEDOT:PSS into the BC matrix. Structural characterization, using scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and x-ray diffraction (XRD) analysis, confirmed the uniform nature of the synthesized BC-AuNPs and BC-AuNPs-PEDOT:PSS composites. Four-point probe analysis indicated that the BC-AuNPs and BC-AuNPs-PEDOT:PSS films had high electrical conductivity. The composites were also tested for biocompatibility with animal osteoblasts (MC3T3-E1). The composite films supported adhesion, growth, and proliferation of MC3T3-E1 cells, indicating that they are biocompatible and non-cytotoxic. AuNPs and PEDOT:PSS, imparted a voltage response, while BC imparted biocompatibility and bio-adhesion to the nanocomposites. Therefore, our BC-AuNPs-PEDOT:PSS composites are candidate materials for biology-device interfaces to produce implantable devices in regenerative medicine. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：865 / 873
页数：9
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