Translating nutritional immunology into drug development for inflammatory bowel disease

被引：3
作者：
Leber, Andrew [1 ]
Hontecillas, Raquel [1 ]
Tubau-Juni, Nuria [1 ]
Bassaganya-Riera, Josep [1 ]
机构：
[1] Virginia Tech, Nutr Immunol & Mol Med Lab, Biocomplex Inst, Blacksburg, VA 24060 USA
来源：
CURRENT OPINION IN GASTROENTEROLOGY | 2016年 / 32卷 / 06期
关键词：
drug development; immunoregulation; inflammatory bowel disease; lanthionine synthetase C-like 2; nutritional immunology; INTESTINAL EPITHELIAL-CELLS; AMELIORATES GLUCOSE-TOLERANCE; OBESITY-RELATED INFLAMMATION; POLYUNSATURATED FATTY-ACIDS; REGULATORY T-CELLS; LONG-TERM INTAKE; C-LIKE PROTEIN-2; PPAR-GAMMA; ULCERATIVE-COLITIS; CROHNS-DISEASE;
D O I：
10.1097/MOG.0000000000000317
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Purpose of reviewTo highlight recent advances in the understanding of nutritional immunology and in the development of novel therapeutics for inflammatory bowel disease (IBD).Recent findingsWe highlight the variety of factors that contribute to the interaction of the immune system and nutrition including the microbiome and the nervous system stimulation of the gut. We describe the potential for therapeutic development in IBD. Further, we review the cellular metabolic effects on immune activation and promising therapeutic targets. Finally, we show how the progression of understanding the role of lanthionine synthetase C-like 2 has encompassed both nutritional and therapeutic advances and led to the development of novel oral small molecule therapeutics for IBD.SummaryNutritional immunology and drug development research centered around immunoregulatory pathways can provide safer and more effective drugs while accelerating the path to cures.
引用
收藏
页码：443 / 449
页数：7
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