Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in Africane-Caribbean and Caucasian patients

被引：28

作者：

Figiel, Sandy ^{[1
]}

Pinault, Michelle ^{[1
]}

Domingo, Isabelle ^{[1
]}

Guimaraes, Cyrille ^{[1
]}

Guibon, Roseline ^{[1
,2
,3
]}

Besson, Pierre ^{[1
]}

Tavernier, Elsa ^{[4
]}

Blanchet, Pascal ^{[5
,6
]}

Multigner, Luc ^{[6
]}

Bruyere, Franck ^{[2
,3
]}

Haillot, Olivier ^{[2
,3
]}

Mathieu, Romain ^{[7
,8
]}

Vincendeau, Sebastien ^{[7
,8
]}

Rioux-Leclercq, Nathalie ^{[7
,8
]}

Lebdai, Souhil ^{[9
]}

Azzouzi, Abdel-Rahmene ^{[9
]}

Perrouin-Verbe, Marie-Aimee ^{[10
,11
]}

Fournier, Georges ^{[10
,11
]}

Doucet, Laurent ^{[10
,11
]}

Rigaud, Jerome ^{[12
,13
]}

Renaudin, Karine ^{[12
,13
]}

Maheo, Karine ^{[1
]}

Fromont, Gaelle ^{[1
,2
,3
]}

机构：

[1] Univ Tours, INSERM U1069, Fac Med, Nutr Croissance & Canc, 10 Bd Tonnelle, F-37032 Tours, France

[2] CHRU Bretonneau, Dept Pathol, Tours, France

[3] CHRU Bretonneau, Dept Urol, Tours, France

[4] CHRU Tours, Clin Investigat Ctr, INSERM 1415, Tours, France

[5] CHU Pointe Pitre, Dept Urol, Les Abymes, Guadeloupe, France

[6] Inserm UMR1085 IRSET, Rennes, France

[7] CHU Rennes, Dept Pathol, Rennes, France

[8] CHU Rennes, Dept Urol, Rennes, France

[9] CHU Angers, Dept Urol, Angers, France

[10] CHU Brest, Dept Pathol, Brest, France

[11] CHU Brest, Dept Urol, Brest, France

[12] CHU Nantes, Dept Pathol, Nantes, France

[13] CHU Nantes, Dept Urol, Nantes, France

来源：

EUROPEAN JOURNAL OF CANCER | 2018年 / 91卷

关键词：

Peri-prostatic adipose tissue; Fatty acids; Prostate cancer; Cancer aggressiveness; Linoleic acid; RISK; CELLS; PROGRESSION; AMERICAN; OBESITY; DIET; MEN;

D O I：

10.1016/j.ejca.2017.12.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Genetic and nutritional factors have been linked to the risk of aggressive prostate cancer (PCa). The fatty acid (FA) composition of peri-prostatic adipose tissue (PPAT), which reflects the past FA intake, is potentially involved in PCa progression. We analysed the FA composition of PPAT, in correlation with the ethno-geographical origin of the patients and markers of tumour aggressiveness. Methods: From a cohort of 1000 men treated for PCa by radical prostatectomy, FA composition of PPAT was analysed in 156 patients (106 Caucasians and 50 African-Caribbeans), 78 with an indolent tumour (ISUP group 1 + pT2 + PSA <10 ng/mL) and 78 with an aggressive tumour (ISUP group 4-5 + pT3). The effect of FA extracted from PPAT on in-vitro migration of PCa cells DU145 was studied in 72 patients, 36 Caucasians, and 36 African-Caribbeans. Results: FA composition differed according to the ethno-geographical origin. Linoleic acid, an essential n-6 FA, was 2-fold higher in African-Caribbeans compared with Caucasian patients, regardless of disease aggressiveness. In African-Caribbeans, the FA profile associated with PCa aggressiveness was characterised by low level of linoleic acid along with high levels of saturates. In Caucasians, a weak and negative association was observed between eicosapentaenoic acid level (an n-3 FA) and disease aggressiveness. In-vitro migration of PCa cells using PPAT from African-Caribbean patients was associated with lower content of linoleic acid. Conclusion: These results highlight an important ethno-geographical variation of PPAT, in both their FA content and association with tumour aggressiveness. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：107 / 115

页数：9

共 36 条

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