Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barre Syndrome, and Microcephaly, Salvador, Brazil

被引：75

作者：

Paploski, Igor A. D. ^{[1
,2
]}

Prates, Ana Paula P. B. ^{[3
]}

Cardoso, Cristiane W. ^{[3
]}

Kikuti, Mariana ^{[1
,2
]}

Silva, Monaise M. O. ^{[1
]}

Waller, Lance A. ^{[4
]}

Reis, Mitermayer G. ^{[1
,2
]}

Kitron, Uriel ^{[1
,4
]}

Ribeiro, Guilherme S. ^{[1
,2
]}

机构：

[1] Ctr Pesquisas Goncalo Moniz, Salvador, BA, Brazil

[2] Univ Fed Bahia, Salvador, BA, Brazil

[3] Secretaria Municipal Saude Salvador, Salvador, BA, Brazil

[4] Emory Univ, Atlanta, GA 30322 USA

来源：

EMERGING INFECTIOUS DISEASES | 2016年 / 22卷 / 08期

关键词：

CHIKUNGUNYA; OUTBREAK; DENGUE; TRANSMISSION; INFECTION;

D O I：

10.3201/eid2208.160496

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. In Salvador, Brazil, outbreaks of acute exanthematous illness (AEI) attributed to Zika virus, Guillain-Barre syndrome (GBS), and microcephaly occurred in 2015. We investigated temporal correlations and time lags between these outbreaks to identify a common link between them by using epidemic curves and time series cross-correlations. Number of GBS cases peaked after a lag of 5-9 weeks from the AEI peak. Number of suspected cases of microcephaly peaked after a lag of 30-33 weeks from the AEI peak, which corresponded to time of potential infections of pregnant mothers during the first trimester. These findings support the association of GBS and microcephaly with Zika virus infection and provide evidence for a temporal relationship between timing of arboviral infection of pregnant women during the first trimester and birth outcome.

引用

页码：1438 / 1444

页数：7

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