Biosynthesis of 3,5-AHBA-derived natural products

被引：103
作者：
Kang, Qianjin [1 ,2 ]
Shen, Yuemao [3 ]
Bai, Linquan [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
[3] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
来源：
NATURAL PRODUCT REPORTS | 2012年 / 29卷 / 02期
基金：
美国国家科学基金会;
关键词：
ACHROMOGENES VAR. RUBRADIRIS; STREPTOMYCES-HYGROSCOPICUS JCM4427; CYCLOHEXANECARBOXYLIC ACID MOIETY; AMYCOLATOPSIS-MEDITERRANEI S699; ANTITUMOR AGENT ANSAMITOCIN; SYNTHASE MODIFICATION STEPS; LEUKEMIA HL-60 CELLS; COENZYME-A REDUCTASE; CHAIN EXTENSION UNIT; ACYL CARRIER PROTEIN;
D O I：
10.1039/c2np00019a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
3-Amino-5-hydroxy benzoic acid (3,5-AHBA) is a precursor for a large group of natural products, including the family of naphthalenic and benzenic ansamycins, the unique saliniketals, and the family of mitomycins. This review covers the biosynthesis of AHBA-derived natural products from a molecular genetics, chemical, and biochemical perspectives, and 174 references are cited.
引用
收藏
页码：243 / 263
页数：21
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