Paradoxical effects of targeting TNF signalling in the treatment of autoimmunity

被引：18

作者：

Chen, Xin ^{[1
,2
]}

Oppenheim, Joost J. ^{[2
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China

[2] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA

来源：

NATURE REVIEWS RHEUMATOLOGY | 2016年 / 12卷 / 11期

关键词：

REGULATORY T-CELLS; EXPANSION;

D O I：

10.1038/nrrheum.2016.145

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adalimumab, an anti-TNF monoclonal antibody used to treat rheumatoid arthritis and other autoimmune disorders, paradoxically enhances the capacity of TNF to expand TNF receptor type II-expressing regulatory T cells. This provocative finding opens a new avenue for exploring the mechanisms that underlie efficacy, non-responsiveness and adverse effects associated with therapeutic targeting of TNF signalling.

引用

页码：625 / 626

页数：2

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