Targeting Mitochondria in Fighting Cancer

被引：49
作者：
Gogvadze, Vladimir [1 ,2 ,3 ]
机构：
[1] Karolinska Inst, Inst Environm Med, Div Toxicol, SE-17177 Stockholm, Sweden
[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia
[3] Inst Theoret & Expt Biophys, Pushchino 142290, Russia
来源：
CURRENT PHARMACEUTICAL DESIGN | 2011年 / 17卷 / 36期
基金：
瑞典研究理事会;
关键词：
Cancer; apoptosis; necrosis; mitochondria; calcium; permeability transition; Bcl-2; PERMEABILITY TRANSITION-PORE; ALPHA-TOCOPHERYL SUCCINATE; APOPTOTIC CELL-DEATH; CYTOCHROME-C RELEASE; VITAMIN-E SUCCINATE; ISOTHIOCYANATE-INDUCED APOPTOSIS; RESPIRATORY COMPLEX-II; RAT-LIVER MITOCHONDRIA; BCL-2 FAMILY PROTEINS; TUMOR-NECROSIS-FACTOR;
D O I：
10.2174/138161211798764933
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
During the last years, there have been a number of reports that prove involvement of mitochondria in the pathogenesis of variety of disorders including cancer and neurodegenerative diseases. Alteration of vital mitochondrial functions - production of ATP, calcium buffering capacity, abnormal production of reactive oxygen species, can be potentially responsible for pathogenesis of cancer and neurodegenerative diseases. Involvement of mitochondria in various types of cell death makes them attractive targets for tumor cell elimination. This review describes the role of mitochondria in tumor cells and how targeting of mitochondria can be used as a tool in fighting cancer.
引用
收藏
页码：4034 / 4046
页数：13
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