Targeting Mitochondria in Fighting Cancer

被引：48

作者：

Gogvadze, Vladimir ^{[1
,2
,3
]}

机构：

[1] Karolinska Inst, Inst Environm Med, Div Toxicol, SE-17177 Stockholm, Sweden

[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

[3] Inst Theoret & Expt Biophys, Pushchino 142290, Russia

来源：

CURRENT PHARMACEUTICAL DESIGN | 2011年 / 17卷 / 36期

基金：

瑞典研究理事会;

关键词：

Cancer; apoptosis; necrosis; mitochondria; calcium; permeability transition; Bcl-2; PERMEABILITY TRANSITION-PORE; ALPHA-TOCOPHERYL SUCCINATE; APOPTOTIC CELL-DEATH; CYTOCHROME-C RELEASE; VITAMIN-E SUCCINATE; ISOTHIOCYANATE-INDUCED APOPTOSIS; RESPIRATORY COMPLEX-II; RAT-LIVER MITOCHONDRIA; BCL-2 FAMILY PROTEINS; TUMOR-NECROSIS-FACTOR;

D O I：

10.2174/138161211798764933

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

During the last years, there have been a number of reports that prove involvement of mitochondria in the pathogenesis of variety of disorders including cancer and neurodegenerative diseases. Alteration of vital mitochondrial functions - production of ATP, calcium buffering capacity, abnormal production of reactive oxygen species, can be potentially responsible for pathogenesis of cancer and neurodegenerative diseases. Involvement of mitochondria in various types of cell death makes them attractive targets for tumor cell elimination. This review describes the role of mitochondria in tumor cells and how targeting of mitochondria can be used as a tool in fighting cancer.

引用

页码：4034 / 4046

页数：13

共 148 条

[1] Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology [J].

Abel, F ;

Sjöberg, RM ;

Nilsson, S ;

Kogner, P ;

Martinsson, T .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (04) :635-646

[2] Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1 - Mapping the site of binding [J].

Abu-Hamad, Salah ;

Zaid, Hilal ;

Israelson, Adrian ;

Nahon, Edna ;

Shoshan-Barmatz, Varda .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (19) :13482-13490

[3] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells [J].

Agapova, L. S. ;

Chernyak, B. V. ;

Domnina, L. V. ;

Dugina, V. B. ;

Efimenko, A. Yu. ;

Fetisova, E. K. ;

Ivanova, O. Yu. ;

Kalinina, N. I. ;

Khromova, N. V. ;

Kopnin, B. P. ;

Kopnin, P. B. ;

Korotetskaya, M. V. ;

Lichinitser, M. R. ;

Lukashev, A. L. ;

Pletjushkina, O. Yu. ;

Popova, E. N. ;

Skulachev, M. V. ;

Shagieva, G. S. ;

Stepanova, E. V. ;

Titova, E. V. ;

Tkachuk, V. A. ;

Vasiliev, J. M. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1300-1316

[4] Mitochondrial metabolism of reactive oxygen species [J].

Andreyev, AI ;

Kushnareva, YE ;

Starkov, AA .

BIOCHEMISTRY-MOSCOW, 2005, 70 (02) :200-214

[5] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence [J].

Anisimov, V. N. ;

Bakeeva, L. E. ;

Egormin, P. A. ;

Filenko, O. F. ;

Isakova, E. F. ;

Manskikh, V. N. ;

Mikhelson, V. M. ;

Panteleeva, A. A. ;

Pasyukova, E. G. ;

Pilipenko, D. I. ;

Piskunova, T. S. ;

Popovich, I. G. ;

Roshchina, N. V. ;

Rybina, O. Yu. ;

Saprunova, V. B. ;

Samoylova, T. A. ;

Semenchenko, A. V. ;

Skulachev, M. V. ;

Spivak, I. M. ;

Tsybul'ko, E. A. ;

Tyndyk, M. L. ;

Vyssokikh, M. Yu. ;

Yurova, M. N. ;

Zabezhinsky, M. A. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1329-1342

[6] GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION [J].

ANKARCRONA, M ;

DYPBUKT, JM ;

BONFOCO, E ;

ZHIVOTOVSKY, B ;

ORRENIUS, S ;

LIPTON, SA ;

NICOTERA, P .

NEURON, 1995, 15 (04) :961-973

[7] Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death [J].

Atlante, A ;

Calissano, P ;

Bobba, A ;

Azzariti, A ;

Marra, E ;

Passarella, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (47) :37159-37166

[8] Increased formation of reactive oxygen species due to glucose depletion in primary cultures of rat thymocytes inhibits proliferation [J].

Aulwurm, UR ;

Brand, KA .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (18) :5693-5698

[9] Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death [J].

Baines, Christopher P. ;

Kaiser, Robert A. ;

Sheiko, Tatiana ;

Craigen, William J. ;

Molkentin, Jeffery D. .

NATURE CELL BIOLOGY, 2007, 9 (05) :550-U122

[10] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke) [J].

Bakeeva, L. E. ;

Barskov, I. V. ;

Egorov, M. V. ;

Isaev, N. K. ;

Kapelko, V. I. ;

Kazachenko, A. V. ;

Kirpatovsky, V. I. ;

Kozlovsky, S. V. ;

Lakomkin, V. L. ;

Levina, S. B. ;

Pisarenko, O. I. ;

Plotnikov, E. Y. ;

Saprunova, V. B. ;

Serebryakova, L. I. ;

Skulachev, M. V. ;

Stelmashook, E. V. ;

Studneva, I. M. ;

Tskitishvili, O. V. ;

Vasilyeva, A. K. ;

Victorov, I. V. ;

Zorov, D. B. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1288-1299

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