Solid phase synthesis of 1,4-benzodiazepine-2,5-diones

被引：93
作者：
Mayer, JP
Zhang, JW
Bjergarde, K
Lenz, DM
Gaudino, JJ
机构：
[1] Amgen Boulder Inc., Boulder, CO 80301
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 45期
关键词：
D O I：
10.1016/0040-4039(96)01845-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,4-benzodinzepine-2,5-diones were synthesized by a simple procedure utilizing polymer supported amino acids and o-nitrobenzoic acids or protected anthranilic acids. Cyclization of the common aminoamide intermediate with concomitant release from the support furnished the desired 1,4-benzodinzepine-2,5-diones. The products were recovered in high yields and exhibited excellent purities. Copyright (C) 1996 Elsevier Science Ltd
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页码：8081 / 8084
页数：4
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