Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained

被引：43
作者：
Dallmann, Andre [1 ]
El-Sagheer, Afaf H. [2 ,3 ]
Dehmel, Lars [1 ]
Muegge, Clemens [1 ]
Griesinger, Christian [4 ]
Ernsting, Nikolaus P. [1 ]
Brown, Tom [2 ]
机构：
[1] Univ Berlin, Dept Chem, D-12489 Berlin, Germany
[2] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England
[3] Suez Canal Univ, Fac Petr & Min Engn, Dept Sci & Math, Chem Branch, Suez 43721, Egypt
[4] Max Planck Inst Biophys Chem, Dept NMR Based Struct Biol, D-37077 Gottingen, Germany
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 52期
关键词：
DNA; DNA recognition; click chemistry; NMR spectroscopy; nucleic acids; IMINO PROTON-EXCHANGE; PCR AMPLIFICATION; TERMINAL ALKYNES; SINGLE-MOLECULE; CLICK CHEMISTRY; SIDE-CHAINS; FUNCTIONALIZATION; CYCLOADDITION; POLYMERASE; KINETICS;
D O I：
10.1002/chem.201102979
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen (see figure). The results explain the surprising biocompatibility of triazole-linked DNA. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：14714 / 14717
页数：4
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