Amyloidosis. Also a Heart Disease

被引：47
作者：
Garcia-Pavia, Pablo [1 ]
Teresa Tome-Esteban, Maria [2 ]
Rapezzi, Claudio [3 ]
机构：
[1] Hosp Univ Puerta Hierro, Serv Cardiol, Secc Insuficiencia Cardiaca & Trasplante, Unidad Miocardiopatias, Madrid 28222, Spain
[2] UCL, Heart Hosp, Dept Cardiol, Inherited Cardiovasc Dis Unit, London, England
[3] Univ Bologna, Policlin S Orsola Malpighi, Ist Cardiol, Bologna, Italy
来源：
REVISTA ESPANOLA DE CARDIOLOGIA | 2011年 / 64卷 / 09期
关键词：
Amyloid; Amyloidosis; Cardiac amyloidosis; STEM-CELL TRANSPLANTATION; CARDIOVASCULAR MAGNETIC-RESONANCE; PRIMARY SYSTEMIC AMYLOIDOSIS; FREE LIGHT-CHAINS; CARDIAC AMYLOIDOSIS; AL AMYLOIDOSIS; CONDUCTION SYSTEM; ECHOCARDIOGRAPHIC FEATURES; LIVER-TRANSPLANTATION; MOLECULAR-MECHANISMS;
D O I：
10.1016/j.recesp.2011.05.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The term cardiac amyloidosis refers to the involvement of the heart as a result of amyloid deposition in heart tissue either in the context of a systemic disease or as a localized form. Several proamyloid proteins can produce amyloid deposits in the heart. Each of these amyloidoses has characteristic clinical (cardiac and extracardiac) features, its own course, and a specific diagnosis and treatment. Since cardiac involvement may be the first-manifestation of amyloidosis, the cardiologist may be the first healthcare professional to see the patient and must always consider this diagnosis. In this review, we consider the amyloidosis characteristics that may present with cardiac involvement, from the cardiologist's viewpoint and in light of our experience. We review in detail when and how to establish the diagnosis and how to treat these patients' cardiac involvement and the underlying amyloid disease.
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收藏
页码：797 / 808
页数：12
相关论文
共 81 条
[1]   Duration of pulmonary venous atrial reversal flow velocity and mitral inflow a wave: New measure of Severity of cardiac amyloidosis [J].
Abdalla, I ;
Murray, RD ;
Lee, JC ;
Stewart, WJ ;
Tajik, AJ ;
Klein, AL .
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 1998, 11 (12) :1125-1133
[2]   Quantitative analysis of serum free light chains - A new marker for the diagnostic evaluation of primary systemic amyloidosis [J].
Abraham, RS ;
Katzmann, JA ;
Clark, RJ ;
Bradwell, AR ;
Kyle, RA ;
Gertz, MA .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2003, 119 (02) :274-278
[3]   Systemic amyloidosis presenting with angina pectoris [J].
Al Suwaidi, J ;
Velianou, JL ;
Gertz, MA ;
Cannon, RO ;
Higano, ST ;
Holmes, DR ;
Lerman, A .
ANNALS OF INTERNAL MEDICINE, 1999, 131 (11) :838-841
[4]   Delayed Hyper-Enhancement Magnetic Resonance Imaging Provides Incremental Diagnostic and Prognostic Utility in Suspected Cardiac Amyloidosis [J].
Austin, Bethany A. ;
Tang, W. H. Wilson ;
Rodriguez, E. Rene ;
Tan, Carmela ;
Flamm, Scott D. ;
Taylor, David O. ;
Starling, Randall C. ;
Desai, Milind Y. .
JACC-CARDIOVASCULAR IMAGING, 2009, 2 (12) :1369-1377
[5]   Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress [J].
Brenner, DA ;
Jain, M ;
Pimentel, DR ;
Wang, B ;
Connors, LH ;
Skinner, M ;
Apstein, CS ;
Liao, RL .
CIRCULATION RESEARCH, 2004, 94 (08) :1008-1010
[6]  
BURROUGHS EI, 1991, BRIT J DISORD COMMUN, V26, P201
[7]   Safety and usefulness of minor salivary gland biopsy: retrospective analysis of 502 procedures performed at a single center [J].
Caporali, Roberto ;
Bonacci, Eleonora ;
Epis, Oscar ;
Bobbio-Pallavicini, Francesca ;
Morbini, Patrizia ;
Montecucco, Carlomaurizio .
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2008, 59 (05) :714-720
[8]   Features and prognosis of exertional syncope in light-chain associated AL cardiac amyloidosis [J].
Chamarthi, B ;
Dubrey, SW ;
Cha, KR ;
Skinner, M ;
Falk, RH .
AMERICAN JOURNAL OF CARDIOLOGY, 1997, 80 (09) :1242-&
[9]   Classification of amyloid deposits in diagnostic cardiac specimens by immunofluorescence [J].
Collins, A. Bernard ;
Smith, R. Neal ;
Stone, James R. .
CARDIOVASCULAR PATHOLOGY, 2009, 18 (04) :205-216
[10]   Autologous stem cell transplantation for primary systemic amyloidosis [J].
Comenzo, RL ;
Gertz, MA .
BLOOD, 2002, 99 (12) :4276-4282
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