Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of thyroid autoimmunity: a narrative review

被引：31

作者：

Gallo, D. ^{[1
]}

Mortara, L. ^{[2
]}

Gariboldi, M. B. ^{[3
]}

Cattaneo, S. A. M. ^{[4
]}

Rosetti, S. ^{[1
]}

Gentile, L. ^{[1
]}

Noonan, D. M. ^{[2
,5
]}

Premoli, P. ^{[1
]}

Cusini, C. ^{[1
]}

Tanda, M. L. ^{[1
]}

Bartalena, L. ^{[1
]}

Piantanida, E. ^{[1
]}

机构：

[1] Univ Insubria, Dept Med & Surg, Endocrine Unit, ASST Sette Laghi, Viale L Borri 57, Varese 21100, Italy

[2] Univ Insubria, Dept Biotechnol & Life Sci, Immunol & Gen Pathol Lab, Varese, Italy

[3] Univ Insubria, Dept Biotechnol & Life Sci, Busto Arsizio, Italy

[4] ASST Sette Laghi, Immunohematol & Transfus Med Unit, Varese, Italy

[5] IRCCS Multimed, Vasc Biol & Angiogenesis Lab, Sci & Technol Pole PST, Milan, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2020年 / 43卷 / 04期

关键词：

Vitamin D; Autoimmunity; Graves' diseases; Hashimoto's thyroiditis; D-RECEPTOR GENE; D-BINDING PROTEIN; HASHIMOTOS-THYROIDITIS; D DEFICIENCY; 1,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D; DOUBLE-BLIND; ENVIRONMENTAL-FACTORS; DENDRITIC CELLS; D INSUFFICIENCY;

D O I：

10.1007/s40618-019-01123-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The main role of vitamin D is to control mineral homeostasis. However, recent studies suggested the existence of a number of extraskeletal effects. Among the latter, preclinical studies provided consistent data on the involvement of vitamin D in innate and adaptive immunity and autoimmunity. Molecular biology studies showed that both vitamin D receptor and vitamin D enzymatic complexes are expressed in a large number of cells and tissues unrelated to mineral homeostasis. In contrast, only a few randomized clinical trials in humans investigated the possible role of vitamin D in the prevention or treatment of immunological disorders. In this regard, low serum vitamin D levels have been reported in observational trials in human autoimmune disorders. The aim of the present paper was to review the potential implications of vitamin D in immune modulation, with special focus on thyroid autoimmune disorders.

引用

页码：413 / 429

页数：17

共 130 条

[1] VITAMIN D RECEPTOR GENE POLYMORPHISM AND ITS ASSOCIATION WITH 1,25-DIHYDROXYVITAMIN D3 IN PATIENTS WITH GRAVES DISEASE IN AN EGYPTIAN POPULATION: A PILOT STUDY
Abd El Gawad, Soma Sherif
Samee, Elham Ragab Abdul
Metwali, Abdelhamid A.
Abd El Gawad, Mohamed Sherif
[J]. ENDOCRINE PRACTICE, 2012, 18 (02) : 132 - 139
[2] Ahn HY, 2017, MED J US, V96, P1
[3] The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding
Ajjan, R. A.
Weetman, A. P.
[J]. HORMONE AND METABOLIC RESEARCH, 2015, 47 (10) : 702 - 710
[4] Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept
Altieri, Barbara
Muscogiuri, Giovanna
Barrea, Luigi
Mathieu, Chantal
Vallone, Carla V.
Mascitelli, Luca
Bizzaro, Giorgia
Altieri, Vincenzo M.
Tirabassi, Giacomo
Balercia, Giancarlo
Savastano, Silvia
Bizzaro, Nicola
Ronchi, Cristina L.
Colao, Annamaria
Pontecorvi, Alfredo
Della Casa, Silvia
[J]. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2017, 18 (03) : 335 - 346
[5] Cannabis: high time for evidence-based policies
不详
[J]. LANCET ONCOLOGY, 2017, 18 (01) : 1 - 1
[6] [Anonymous], 2018, DIABETES CARE S1, V2018, pS1
[7] [Anonymous], 2015, MEDICINE, V94, pe1435
[8] [Anonymous], 1919, SUDHOFFS ARCH GESCH, V11, P74
[9] [Anonymous], 2014, IEEE COMPUTATIONAL INTELLIGENCE MAGAZINE, VXX, P60, DOI [10.1017/CBO9781107415324.004, DOI 10.1017/CBO9781107415324.004]
[10] Autier P, 2017, LANCET DIABETES ENDO, V17, P8587

← 1 2 3 4 5 6 7 8 9 10 →