Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships

被引：50

作者：

Molina-Montes, Esther ^{[1
,2
]}

Van Hoogstraten, Lisa ^{[1
,2
]}

Gomez-Rubio, Paulina ^{[1
,2
]}

Lohr, Matthias ^{[3
,4
]}

Sharp, Linda ^{[5
,6
,7
]}

Molero, Xavier ^{[8
]}

Marquez, Mirari ^{[1
,2
]}

Michalski, Christoph W. ^{[9
,10
]}

Farre, Antoni ^{[11
]}

Perea, Jose ^{[12
,13
,14
]}

O'Rorke, Michael ^{[15
,16
]}

Greenhalf, William ^{[17
]}

Ilzarbe, Lucas ^{[18
]}

Tardon, Adonina ^{[19
]}

Gress, Thomas M. ^{[20
]}

Barbera, Victor M. ^{[21
]}

Crnogorac-Jurcevic, Tatjana ^{[22
]}

Munoz-Bellvis, Luis ^{[23
]}

Dominguez-Munoz, Enrique ^{[24
]}

Balsells, Joaquim ^{[8
]}

Costello, Eithne ^{[17
]}

Iglesias, Mar ^{[18
]}

Kleeff, Jorg ^{[9
,10
]}

Kong, Bo ^{[9
]}

Mora, Josefina ^{[11
]}

O'Driscoll, Damian ^{[5
,6
]}

Poves, Ignasi ^{[18
]}

Scarpa, Aldo ^{[25
,26
]}

Yu, Jingru ^{[27
]}

Ye, Weimin ^{[27
]}

Hidalgo, Manuel ^{[28
,29
]}

Carrato, Alfredo ^{[30
,31
]}

Lawlor, Rita ^{[25
,26
]}

Real, Francisco X. ^{[31
,32
,33
]}

Malats, Nuria ^{[1
,2
]}

机构：

[1] Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain

[2] CIBERONC, Madrid, Spain

[3] Karolinska Inst, Gastrocentrum, Stockholm, Sweden

[4] Univ Hosp, Stockholm, Sweden

[5] Univ Coll Cork, Natl Canc Registry Ireland, Cork, Ireland

[6] Univ Coll Cork, HRB Clin Res Facil, Cork, Ireland

[7] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England

[8] Univ Autonoma Barcelona, Hosp Univ Vall Hebron, Vall Hebron Res Inst VHIR, CIBEREHD, Barcelona, Spain

[9] Tech Univ Munich, Dept Surg, Munich, Germany

[10] Martin Luther Univ Halle Wittenberg, Dept Visceral Vasc & Endocrine Surg, Halle, Saale, Germany

[11] Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona, Spain

[12] Hosp 12 Octubre, Dept Surg, Madrid, Spain

[13] Fdn Jimenez Diaz, Dept Surg, Madrid, Spain

[14] Fdn Jimenez Diaz, Hlth Res Inst, Madrid, Spain

[15] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland

[16] Univ Iowa, Coll Publ Hlth, Iowa City, IA USA

[17] Royal Liverpool Univ Hosp, Dept Mol & Clin Canc Med, Liverpool, Merseyside, England

[18] Hosp del Mar Parc Salut Mar, CIBERONC, Barcelona, Spain

[19] CIBERESP, Inst Univ Oncol Principado Asturias, Dept Med, Oviedo, Spain

[20] Univ Hosp Giessen & Marburg, Dept Gastroenterol, Marburg, Germany

[21] Gen Univ Hosp Elche, Mol Genet Lab, Elche, Spain

[22] Queen Mary Univ London, Ctr Mol Oncol, Barts Canc Inst, London, England

[23] Salamanca Univ Hosp, Gen & Digest Surg Dept, Salamanca, Spain

[24] Univ Clin Hosp Santiago de Compostela, Dept Gastroenterol, Santiago, Spain

[25] Univ & Hosp Trust Verona, ARC Net Ctr Appl Res Canc, Verona, Italy

[26] Univ & Hosp Trust Verona, Dept Pathol & Diagnost, Verona, Italy

[27] Karolinska Inst, Dept Med Epidemiol & Biostat, Stokholm, Sweden

[28] Madrid Norte Sanchinarro Hosp, Madrid, Spain

[29] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

[30] Alcala Univ, Ramon y Cajal Univ Hosp, Dept Oncol, IRYCIS, Madrid, Spain

[31] CIBERONC, Madrid, Spain

[32] Epithelial Carcinogenesis Grp, Madrid, Spain

[33] Spanish Natl Canc Res Ctr CNIO, Madrid, Spain

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2020年 / 29卷 / 05期

基金：

欧盟第七框架计划;

关键词：

CIGARETTE-SMOKING; BLADDER-CANCER; LUNG-CANCER; METHYLATION; SMOKERS; PHARYNX; MALES;

D O I：

10.1158/1055-9965.EPI-19-1027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to lifespan smoking patterns and other smoking features, such as tobacco type. Our aim was to deeply investigate them within a large European case-control study. Methods: Tobacco smoking habits and other relevant information were obtained from 2,009 cases and 1,532 controls recruited in the PanGenEU study using standardized tools. Multivariate logistic regression analysis was performed to evaluate pancreatic cancer risk by smoking characteristics and interactions with other pancreatic cancer risk factors. Fractional polynomials and restricted cubic splines were used to test for nonlinearity of the dose-response relationships and to analyze their shape. Results: Relative to never-smokers, current smokers [OR = 1.72; 95% confidence interval (95% CI), 1.39-2.12], those inhaling into the throat (OR = 1.48; 95% CI, 1.11-1.99) or chest (OR = 1.33; 95% CI, 1.12-1.58), and those using nonfiltered cigarettes (OR = 1.69; 95% CI, 1.10-2.61), were all at an increased pancreatic cancer risk. Pancreatic cancer risk was highest in current black tobacco smokers (OR = 2.09; 95% CI, 1.31-3.41), followed by blond tobacco smokers (OR = 1.43; 95% CI, 1.01-2.04). Childhood exposure to tobacco smoke relative to parental smoking was also associated with increased pancreatic cancer risk (OR = 1.24; 95% CI, 1.03-1.49). Dose-response relationships for smoking duration, intensity, cumulative dose, and smoking cessation were nonlinear and showed different shapes by tobacco type. Effect modification by family history of pancreatic cancer and diabetes was likely. Conclusions: This study reveals differences in pancreatic cancer risk by tobacco type and other habit characteristics, as well as nonlinear risk associations. Impact: This characterization of smoking-related pancreatic cancer risk profiles may help in defining pancreatic cancer high-risk populations.

引用

页码：1009 / 1018

页数：10

共 42 条

[1] Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries [J].

Allemani, Claudia ;

Matsuda, Tomohiro ;

Di Carlo, Veronica ;

Harewood, Rhea ;

Matz, Melissa ;

Niksic, Maja ;

Bonaventure, Audrey ;

Valkov, Mikhail ;

Johnson, Christopher J. ;

Esteve, Jacques ;

Ogunbiyi, Olufemi J. ;

Azevedo e Silva, Gulnar ;

Chen, Wan-Qing ;

Eser, Sultan ;

Engholm, Gerda ;

Stiller, Charles A. ;

Monnereau, Alain ;

Woods, Ryan R. ;

Visser, Otto ;

Lim, Gek Hsiang ;

Aitken, Joanne ;

Weir, Hannah K. ;

Coleman, Michel P. .

LANCET, 2018, 391 (10125) :1023-1075

[2] Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study [J].

Ambatipudi, Srikant ;

Cuenin, Cyrille ;

Hernandez-Vargas, Hector ;

Ghantous, Akram ;

Le Calvez-Kelm, Florence ;

Kaaks, Rudolf ;

Barrdahl, Myrto ;

Boeing, Heiner ;

Aleksandrova, Krasimira ;

Trichopoulou, Antonia ;

Lagiou, Pagona ;

Naska, Androniki ;

Palli, Domenico ;

Krogh, Vittorio ;

Polidoro, Silvia ;

Tumino, Rosario ;

Panico, Salvatore ;

Bueno-de-Mesquita, Bas ;

Peeters, Petra H. M. ;

Quiros, Jose Ramon ;

Navarro, Carmen ;

Ardanaz, Eva ;

Dorronsoro, Miren ;

Key, Tim ;

Vineis, Paolo ;

Murphy, Neil ;

Riboli, Elio ;

Romieu, Isabelle ;

Herceg, Zdenko .

EPIGENOMICS, 2016, 8 (05) :599-618

[3] Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4) [J].

Bertuccio, P. ;

La Vecchia, C. ;

Silverman, D. T. ;

Petersen, G. M. ;

Bracci, P. M. ;

Negri, E. ;

Li, D. ;

Risch, H. A. ;

Olson, S. H. ;

Gallinger, S. ;

Miller, A. B. ;

Bueno-de-Mesquita, H. B. ;

Talamini, R. ;

Polesel, J. ;

Ghadirian, P. ;

Baghurst, P. A. ;

Zatonski, W. ;

Fontham, E. T. ;

Bamlet, W. R. ;

Holly, E. A. ;

Lucenteforte, E. ;

Hassan, M. ;

Yu, H. ;

Kurtz, R. C. ;

Cotterchio, M. ;

Su, J. ;

Maisonneuve, P. ;

Duell, E. J. ;

Bosetti, C. ;

Boffetta, P. .

ANNALS OF ONCOLOGY, 2011, 22 (06) :1420-1426

[4] Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4) [J].

Bosetti, C. ;

Lucenteforte, E. ;

Silverman, D. T. ;

Petersen, G. ;

Bracci, P. M. ;

Ji, B. T. ;

Negri, E. ;

Li, D. ;

Risch, H. A. ;

Olson, S. H. ;

Gallinger, S. ;

Miller, A. B. ;

Bueno-de-Mesquita, H. B. ;

Talamini, R. ;

Polesel, J. ;

Ghadirian, P. ;

Baghurst, P. A. ;

Zatonski, W. ;

Fontham, E. ;

Bamlet, W. R. ;

Holly, E. A. ;

Bertuccio, P. ;

Gao, Y. T. ;

Hassan, M. ;

Yu, H. ;

Kurtz, R. C. ;

Cotterchio, M. ;

Su, J. ;

Maisonneuve, P. ;

Duell, E. J. ;

Boffetta, P. ;

La Vecchia, C. .

ANNALS OF ONCOLOGY, 2012, 23 (07) :1880-1888

[5] Exposure to environmental tobacco smoke in childhood and incidence of cancer in adulthood in never smokers in the European prospective investigation into cancer and nutrition [J].

Chuang, Shu-Chun ;

Gallo, Valentina ;

Michaud, Dominique ;

Overvad, Kim ;

Tjonneland, Anne ;

Clavel-Chapelon, Francoise ;

Romieu, Isabelle ;

Straif, Kurt ;

Palli, Domenico ;

Pala, Valeria ;

Tumino, Rosario ;

Sacerdote, Carlotta ;

Panico, Salvatore ;

Peeters, Petra H. ;

Lund, Eiliv ;

Gram, Inger Torhild ;

Manjer, Jonas ;

Borgquist, Signe ;

Riboli, Elio ;

Vineis, Paolo .

CANCER CAUSES & CONTROL, 2011, 22 (03) :487-494

[6] TOBACCO AND BLADDER-CANCER IN MALES - INCREASED RISK FOR INHALERS AND SMOKERS OF BLACK TOBACCO [J].

CLAVEL, J ;

CORDIER, S ;

BOCCONGIBOD, L ;

HEMON, D .

INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (04) :605-610

[7] Smoking patterns and cancer of the oral cavity and pharynx: a case-control study in Uruguay [J].

De Stefani, E ;

Boffetta, P ;

Oreggia, F ;

Mendilaharsu, M ;

Deneo-Pellegrini, H .

ORAL ONCOLOGY, 1998, 34 (05) :340-346

[8] FLEXIBLE REGRESSION-MODELS WITH CUBIC-SPLINES [J].

DURRLEMAN, S ;

SIMON, R .

STATISTICS IN MEDICINE, 1989, 8 (05) :551-561

[9] Reduced risk of pancreatic cancer associated with asthma and nasal allergies [J].

Gomez-Rubio, Paulina ;

Zock, Jan-Paul ;

Rava, Marta ;

Marquez, Mirari ;

Sharp, Linda ;

Hidalgo, Manuel ;

Carrato, Alfredo ;

Ilzarbe, Lucas ;

Michalski, Christoph ;

Molero, Xavier ;

Farre, Antoni ;

Perea, Jose ;

Greenhalf, William ;

O'Rorke, Michael ;

Tardon, Adonina ;

Gress, Thomas ;

Barbera, Victor ;

Crnogorac-Jurcevic, Tatjana ;

Dominguez-Munoz, Enrique ;

Munoz-Bellvis, Luis ;

Alvarez-Urturi, Cristina ;

Balcells, Joaquim ;

Barneo, Luis ;

Costello, Eithne ;

Guillen-Ponce, Carmen ;

Kleeff, Joerg ;

Kong, Bo ;

Lawlor, Rita ;

Lohr, Matthias ;

Mora, Josefina ;

Murray, Lim ;

O'Driscoll, Damian ;

Pelaez, Pablo ;

Poves, Ignasi ;

Scarpa, Aldo ;

Real, Francisco X. ;

Malats, Nuria .

GUT, 2017, 66 (02) :314-+

[10]

Harald B, 2012, STAT MED, V32, P2262

← 1 2 3 4 5 →