Glutamine enhances glucose-induced mesangial cell proliferation

被引：13

作者：

Lagranha, Claudia J. ^{[1
]}

Doi, Sonia Q. ^{[2
]}

Pithon-Curi, Tania C. ^{[3
]}

Curi, Rui ^{[1
]}

Sellitti, Donald F. ^{[2
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Phys & Biophys, BR-05508900 Sao Paulo, Brazil

[2] Univ Hlth Sci, Uniformed Serv, Bethesda, MD USA

[3] Univ Cruzeiro Sul, Biol Sci & Hlth Ctr, Sao Paulo, SP, Brazil

来源：

AMINO ACIDS | 2008年 / 34卷 / 04期

关键词：

glutamine; supplementation; kidney disease; mesangial cell; cell proliferation;

D O I：

10.1007/s00726-007-0002-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proliferation of mesangial cells (MC) in the presence of glutamine (0-20 mM) was determined in both low (5 mM) and high (25 mM) glucose-containing medium. Glutamine in a high glucose (HG) environment increased cell proliferation in a dose-dependent manner. Inhibition of glutamine:fructose 6-phosphate amidotransferase (GFAT) and of phosphodiesterase significantly reduced glutamine-induced proliferation. Supraphysiologic levels of glutamine increase MC proliferation in a HG milieu via GFAT and cAMP-dependent pathways, suggesting that glutamine could pose a risk for diabetic nephropathy.

引用

页码：683 / 685

页数：3

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