Glutamine enhances glucose-induced mesangial cell proliferation

被引：13
|
作者：
Lagranha, Claudia J. [1 ]
Doi, Sonia Q. [2 ]
Pithon-Curi, Tania C. [3 ]
Curi, Rui [1 ]
Sellitti, Donald F. [2 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Phys & Biophys, BR-05508900 Sao Paulo, Brazil
[2] Univ Hlth Sci, Uniformed Serv, Bethesda, MD USA
[3] Univ Cruzeiro Sul, Biol Sci & Hlth Ctr, Sao Paulo, SP, Brazil
来源：
AMINO ACIDS | 2008年 / 34卷 / 04期
关键词：
glutamine; supplementation; kidney disease; mesangial cell; cell proliferation;
D O I：
10.1007/s00726-007-0002-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proliferation of mesangial cells (MC) in the presence of glutamine (0-20 mM) was determined in both low (5 mM) and high (25 mM) glucose-containing medium. Glutamine in a high glucose (HG) environment increased cell proliferation in a dose-dependent manner. Inhibition of glutamine:fructose 6-phosphate amidotransferase (GFAT) and of phosphodiesterase significantly reduced glutamine-induced proliferation. Supraphysiologic levels of glutamine increase MC proliferation in a HG milieu via GFAT and cAMP-dependent pathways, suggesting that glutamine could pose a risk for diabetic nephropathy.
引用
收藏
页码：683 / 685
页数：3
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