Solid supported aryl/heteroaryl C-N cross-coupling reactions.

被引：139
|
作者：
Combs, AP [1 ]
Saubern, S [1 ]
Rafalski, M [1 ]
Lam, PYS [1 ]
机构：
[1] Dupont Merck Pharmaceut Co, Expt Stn, Chem & Phys Sci Dept, Wilmington, DE 19880 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 09期
关键词：
arylation; coupling reactions; microwave heating; polymer support;
D O I：
10.1016/S0040-4039(99)00026-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report herein the first examples of polymer supported aryl-heteroaryl C-N cross-coupling reactions and dramatically decreased reaction times upon microwave irradiation; The methodology provides easy access to N-arylated heterocycles from heterocycles bearing an N-H bond and readily available arylboronic acids in the presence of copper(II) acetate and pyridine. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1623 / 1626
页数：4
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