Solid supported aryl/heteroaryl C-N cross-coupling reactions.

被引：139

作者：

Combs, AP ^{[1
]}

Saubern, S ^{[1
]}

Rafalski, M ^{[1
]}

Lam, PYS ^{[1
]}

机构：

[1] Dupont Merck Pharmaceut Co, Expt Stn, Chem & Phys Sci Dept, Wilmington, DE 19880 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 09期

关键词：

arylation; coupling reactions; microwave heating; polymer support;

D O I：

10.1016/S0040-4039(99)00026-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report herein the first examples of polymer supported aryl-heteroaryl C-N cross-coupling reactions and dramatically decreased reaction times upon microwave irradiation; The methodology provides easy access to N-arylated heterocycles from heterocycles bearing an N-H bond and readily available arylboronic acids in the presence of copper(II) acetate and pyridine. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1623 / 1626

页数：4

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